The Higher Number and Longer Duration of Kenogen Hairs Are the Main Cause of the Hair Rarefaction in Androgenetic Alopecia.
Androgenetic alopecia
Baldness
Finasteride
Hair cycle
Kenogen
Journal
Skin appendage disorders
ISSN: 2296-9195
Titre abrégé: Skin Appendage Disord
Pays: Switzerland
ID NLM: 101670617
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
received:
07
06
2018
accepted:
07
09
2018
entrez:
4
5
2019
pubmed:
3
5
2019
medline:
3
5
2019
Statut:
ppublish
Résumé
The progressive reduction of the number of terminal hairs and the simultaneous increase in the number of vellus hairs (hair miniaturization) are the current explanation of human baldness. In a 2.5-year study on 43 male subjects with androgenetic alopecia (AGA), we found that oral finasteride augmented the total number of hairs by 55%, but failed to decrease the prevalence of vellus hairs. While our data may explain why, in AGA, hairs become progressively softer and combable, they cannot explain why areas of hair rarefaction develop. We propose that the longer duration and higher frequency of kenogen hairs are the real mechanism through which the scalp hairs rarefy.
Identifiants
pubmed: 31049336
doi: 10.1159/000493587
pii: sad-0005-0152
pmc: PMC6489042
doi:
Types de publication
Journal Article
Langues
eng
Pagination
152-154Références
Br J Dermatol. 2000 Oct;143(4):804-10
pubmed: 11069460
Dermatology. 2002;205(2):108-10
pubmed: 12218222
Dermatology. 2005;210(1):18-20
pubmed: 15604539
J Am Acad Dermatol. 2006 Jul;55(1):71-4
pubmed: 16781295
Exp Dermatol. 2016 Jun;25(6):482-4
pubmed: 26782302
Exp Dermatol. 2016 Jun;25(6):424-5
pubmed: 27061176
Skin Pharmacol. 1994;7(1-2):84-9
pubmed: 8003330
Dermatology. 1998;197(4):335-7
pubmed: 9873170