Genome-wide association study of type 2 diabetes in Africa.
Africa
Established loci
Fine-mapping
Genome-wide association study
Type 2 diabetes
Journal
Diabetologia
ISSN: 1432-0428
Titre abrégé: Diabetologia
Pays: Germany
ID NLM: 0006777
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
12
09
2018
accepted:
22
03
2019
pubmed:
3
5
2019
medline:
17
3
2020
entrez:
4
5
2019
Statut:
ppublish
Résumé
Genome-wide association studies (GWAS) for type 2 diabetes have uncovered >400 risk loci, primarily in populations of European and Asian ancestry. Here, we aimed to discover additional type 2 diabetes risk loci (including African-specific variants) and fine-map association signals by performing genetic analysis in African populations. We conducted two type 2 diabetes genome-wide association studies in 4347 Africans from South Africa, Nigeria, Ghana and Kenya and meta-analysed both studies together. Likely causal variants were identified using fine-mapping approaches. The most significantly associated variants mapped to the widely replicated type 2 diabetes risk locus near TCF7L2 (p = 5.3 × 10 These results demonstrate the value of performing GWAS in Africans, provide a resource to larger consortia for further discovery and fine-mapping and indicate that additional large-scale efforts in Africa are warranted to gain further insight in to the genetic architecture of type 2 diabetes.
Identifiants
pubmed: 31049640
doi: 10.1007/s00125-019-4880-7
pii: 10.1007/s00125-019-4880-7
pmc: PMC6560001
doi:
Substances chimiques
Transcription Factor 7-Like 2 Protein
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1204-1211Subventions
Organisme : Wellcome Trust
ID : 098381
Pays : United Kingdom
Organisme : NIDDK NIH HHS
ID : U01 DK085545
Pays : United States
Organisme : Wellcome Trust
ID : 090367
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 203141
Pays : United Kingdom
Organisme : NIDDK NIH HHS
ID : R01 DK098032
Pays : United States
Organisme : Wellcome Trust
ID : 106130
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 090532
Pays : United Kingdom
Organisme : NIDDK NIH HHS
ID : U01 DK105535
Pays : United States
Organisme : Medical Research Council
ID : MR/K013491/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : WT206194
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0601261
Pays : United Kingdom
Organisme : NHGRI NIH HHS
ID : ZIA HG200362
Pays : United States
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