Radiological investigation of gunshot wounds: a systematic review of published evidence.

Firearm Forensic pathology Forensic radiology Systematic review Terminal ballistics

Journal

International journal of legal medicine
ISSN: 1437-1596
Titre abrégé: Int J Legal Med
Pays: Germany
ID NLM: 9101456

Informations de publication

Date de publication:
Jul 2019
Historique:
received: 02 11 2018
accepted: 16 04 2019
pubmed: 3 5 2019
medline: 3 1 2020
entrez: 4 5 2019
Statut: ppublish

Résumé

Despite the constantly growing popularity of radiological imaging in forensic pathology, a systematic review investigating the efficiency and limits of radiological techniques, in comparison to forensic autopsy, was still missing. The present review aims at providing an overview on the current role of radiology in the forensic investigation of fatal gunshot wounds without any restriction to specific radiological techniques. A systematic literature search on three databases (PubMed, Web of Science, and Science Direct) was performed until December 2017. The Oxford Centre for Evidence Based Medicine (OCEBM) grading system for levels of evidence was applied, in order to weigh published evidence. Eighty-six papers (1.64% of the records) were included. Despite the quite limited general level of evidence, which contrasts with the abundance of the scientific literature on this topic, several recommendations/statements, coupled to their OCEBM grade, were distilled as for the identification of retained bullets, gunshot wounds detection, diagnosis of entrance and exit wounds, trajectories and internal injury detection and estimation of the firing distance. Imaging radiological technologies represent the present and future of wound ballistics. However, traditional, micro and molecular imaging techniques require further validation through blinded cross-sectional studies with appropriate reference standards (e.g. forensic autopsy).

Identifiants

pubmed: 31049663
doi: 10.1007/s00414-019-02071-8
pii: 10.1007/s00414-019-02071-8
doi:

Types de publication

Journal Article Systematic Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

1149-1158

Références

Messmer JM, Fierro MF (1986) Radiologic forensic investigation of fatal gunshot wounds. Radiographics 6(3):457–473
pubmed: 3685503
Thali MJ, Yen K, Vock P, Ozdoba C, Kneubuehl BP, Sonnenschein M, Dirnhofer R (2003) Image-guided virtual autopsy findings of gunshot victims performed with multi-slice computed tomography and magnetic resonance imaging and subsequent correlation between radiology and autopsy findings. Forensic Sci Int 138(1–3):8–16
pubmed: 14642714
Thali MJ, Viner MD, Brogdon BG (2010) Brogdon’s forensic radiology, 2nd edn. CRC Press, Boca Raton
Metter D, Stute H, Rauschke J (1989) Forensic medicine roentgen studies in gunshot wounds of the skull. Beitr Gerichtl Med 47:473–477
pubmed: 2818520
Dirnhofer R, Jackowski C, Vock P, Potter K, Thali MJ (2006) VIRTOPSY: minimally invasive, imaging-guided virtual autopsy. Radiographics 26(5):1305–1333
pubmed: 16973767
Bolliger SA, Thali MJ, Gascho D, Poschmann SA, Eggert S (2017) Movement of steel-jacketed projectiles in biological tissue in the magnetic field of a 3-T magnetic resonance unit. Int J Legal Med 131(5):1363–1368
pubmed: 28303395
Eggert S, Kubik-Huch RA, Lory M, Froehlich JM, Gascho D, Thali MJ, Bolliger SA (2015) The influence of 1.5 and 3 T magnetic resonance unit magnetic fields on the movement of steel-jacketed projectiles in ordnance gelatin. Forensic Sci Med Pathol 11(4):544–551
pubmed: 26514689
Luijten M, Haest II, van Kan RA, van Lohuizen W, Kroll J, Schnerr RS, Hermsen R, Hofman PA (2016) Can postmortem MRI be used to assess trajectories in gunshot victims? Int J Legal Med 130(2):457–462
pubmed: 26518298
Gascho D, Ampanozi G, Ebert L, Bolliger S, Eggert S, Franckenberg S, Thali M, Flach P (2016) A moot point! A homicide case report on ambiguous projectile movement on postmortem MR. J Forensic Radiol Imaging 5:62–67
Oehmichen M, Gehl H-BB, Meissner C, Petersen D, Höche W, Gerling I, König HG (2003) Forensic pathological aspects of postmortem imaging of gunshot injury to the head: documentation and biometric data. Acta Neuropathol 105(6):570–580
pubmed: 12664319
Grabherr S, Grimm JM, Heinemann A (2016) Atlas of postmortem angiography. Springer-Verlag, Heidelberg
Dedini RD, Karacozoff AM, Shellock FG, Xu D, McClellan RT, Pekmezci M (2013) MRI issues for ballistic objects: information obtained at 1.5-, 3- and 7-Tesla. Spine J 13(7):815–822
pubmed: 23562330
Rutty GN, Brough A, Biggs MJ, Robinson C, Lawes SD, Hainsworth SV (2013) The role of micro-computed tomography in forensic investigations. Forensic Sci Int 225(1–3):60–66
pubmed: 23153801
OCEBM Levels of Evidence Working Group. Howick J, Chalmers I, Glasziou P, Greenhalgh T, Heneghan C, Liberati A, Moschetti I, Phillips B, Thornton H, Goddard O, Hodgkinson M (2011) The Oxford levels of evidence 2. Oxford Centre for Evidence-Based Medicine. https://www.cebm.net/index.aspx?o=5653 . Accessed 24 October 2018
Bowen DAL (1966) The role of radiology and the identification of foreign bodies at post mortem examination. J Forensic Sci Soc 6(1):28–32
Pinto A, Brunese L, Scaglione M, Scuderi MG, Romano L (2009) Gunshot injuries in the neck area: ballistics elements and forensic issues. Semin Ultrasound CT MR 30(3):215–220
pubmed: 19537054
Navarro JA, Cortés E, Sanz CL, Pellicer MA (1991) Finding of a bullet in the cervical column of a body hit by a train. J Forensic Sci 36(2):602–606
pubmed: 2066735
McNulty JP, Gapert R (2013) Forensic anthropology and radiography in the examination of an unknown mummified hand. Forensic Sci Med Pathol 9(4):602–606
pubmed: 23765640
Tsuboi A, Satoh F, Seto Y, Medicine O-M (2014) Self-inflicted fatal shotgun wound from a homemade weapon. Leg Med (Tokyo) 16(2):81–83
Tattoli L, Schmid S, Tsokos M (2014) Three rounds as “tandem bullets”: unusual findings in a case of a suicidal gunshot to the head. Forensic Sci Med Pathol 10(4):613–618
pubmed: 25091600
Ampanozi G, Schwendener N, Krauskopf A, Thali MJ, Bartsch C (2013) Incidental occult gunshot wound detected by postmortem computed tomography. Forensic Sci Med Pathol 9(1):68–72
pubmed: 22956431
Harcke HT, Levy AD, Abbott RM, Mallak CT, Getz JM, Champion HR, Pearse L (2007) Autopsy radiography: digital radiographs (DR) vs multidetector computed tomography (MDCT) in high-velocity gunshot-wound victims. Am J Forensic Med Pathol 28(1):13–19
pubmed: 17325457
Dodd GD 3rd, Budzik RF Jr (1990) Identification of retained firearm projectiles on plain radiographs. AJR Am J Roentgenol 154:471–475
pubmed: 2106206
Jeffery AJ, Rutty GN, Robinson C, Morgan B (2008) Computed tomography of projectile injuries. Clin Radiol 63(10):1160–1166
pubmed: 18774364
Hejna P, Zátopková L, Safr M, Straka L (2013) Circular saw-associated fatality mimicking gunshot injury. J Forensic Sci 58(Suppl 1):S267–S269
pubmed: 23181567
Graham EW, Tawadros AM, Prahlow JA (2014) Decreased subject contrast and summation artifact: an explanation for a nearly imperceptible bullet by X-ray examination. Am J Forensic Med Pathol 35(4):249–252
pubmed: 25361062
Wade AD, Conlogue GJ (2013) Forensic considerations for preprocessing effects on clinical MDCT scans. J Forensic Sci 58(3):797–803
pubmed: 23406397
Miller CR, Haag M, Gerrard C, Hatch GM, Elifritz J, Simmons MC, Lathrop S, Nolte KB (2016) Comparative evaluation of potentially radiolucent projectile components by radiographs and computed tomography. J Forensic Sci 61(6):1563–1570
pubmed: 27787896
Kirchhoff SM, Scaparra EF, Grimm J, Scherr M, Graw M, Reiser MF, Peschel O (2016) Postmortem computed tomography (PMCT) and autopsy in deadly gunshot wounds--a comparative study. Int J Legal Med 130(3):819–826
pubmed: 26156451
Levy AD, Abbott RM, Mallak CT, Getz JM, Harcke HT, Champion HR, Pearse LA (2006) Virtual autopsy: preliminary experience in high-velocity gunshot wound victims. Radiology 240(2):522–528
pubmed: 16801370
Clark KR (2016) Imaging assessment of gunshot injuries. Radiol Technol 87(6):627–644
pubmed: 27390231
Karger B, Puskas Z, Ruwald B, Teige K, Schuirer G (1998) Morphological findings in the brain after experimental gunshots using radiology, pathology and histology. Int J Legal Med 111(6):314–319
pubmed: 9826091
Puentes K, Taveira F, Madureira AJJ, Santos A, Magalhães T (2009) Three-dimensional reconstitution of bullet trajectory in gunshot wounds: a case report. J Forensic Legal Med 16(7):407–410
Thomsen AH, Jurik AG, Uhrenholt L, Vesterby A (2009) An alternative approach to computerized tomography (CT) in forensic pathology. Forensic Sci Int 183(1–3):87–90
pubmed: 19070977
Leth PM (2009) Computerized tomography used as a routine procedure at postmortem investigations. Am J Forensic Med Pathol 30(3):219–222
pubmed: 19696574
Von See C, Bormann K-HH, Schumann P, Goetz F, Gellrich N-CC, Rücker M (2009) Forensic imaging of projectiles using cone-beam computed tomography. Forensic Sci Int 190(1–3):38–41
Yong TE (2017) A systematic review on ricochet gunshot injuries. Leg Med (Tokyo) 26:45–51
Flach P, Ampanozi G, Germerott T, Ross S, Krauskopf A, Thali M, Mund M (2013) Shot sequence detection aided by postmortem computed tomography in a case of homicide. J Forensic Radiol Imaging 1(2):68–72
Maiese A, Gitto L, De Matteis A, Panebianco V, Bolino G (2014) Post mortem computed tomography: useful or unnecessary in gunshot wounds deaths? Two case reports. Leg Med (Tokyo) 16(6):357–363
Viero A, Giraudo C, Cecchetto G, Muscovich C, Favretto D, Puglisi M, Fais P, Viel G (2014) An unusual case of “dyadic-death” with a single gunshot. Forensic Sci Int 244:e1–e5
pubmed: 25194714
Usui A, Kawasumi Y, Hosokai Y, Kozakai M, Saito H, Funayama M (2016) Usefulness and limitations of postmortem computed tomography in forensic analysis of gunshot injuries: three case reports. Leg Med (Tokyo) 18:98–103
Van Kan RAT, Haest IIH, Lahaye MJ, Hofman PAM (2017) The diagnostic value of forensic imaging in fatal gunshot incidents: a review of literature. J Forensic Radiol Imaging 10:9–14
Garetier M, Deloire L, Dédouit F, Dumousset E, Saccardy C, Ben Salem D (2017) Postmortem computed tomography findings in suicide victims. Diagn Interv Imaging 98(2):101–112
pubmed: 27687828
Andenmatten MA, Thali MJ, Kneubuehl BP, Oesterhelweg L, Ross S, Spendlove D, Bolliger SA (2008) Gunshot injuries detected by post-mortem multislice computed tomography (MSCT): a feasibility study. Leg Med (Tokyo) 10(6):287–292
Krispin A, Zaitsev K, Hiss J (2010) The elusive slug: bullet intestinal “embolism”. Forensic Sci Med Pathol 6(4):288–292
pubmed: 20473791
Hanna TN, Shuaib W, Han T, Mehta A, Khosa F (2015) Firearms, bullets, and wound ballistics: an imaging primer. Injury 46(7):1186–1196
pubmed: 25724396
Chute DJ, Newman K, Bready RJ, Benjamin ED (2017) Case report of a migrating bullet: an unusual cause of postmortem confusion. J Forensic Sci 62(5):1386–1388
pubmed: 28217834
Makhlouf F, Scolan V, Ferretti G, Stahl C, Paysant F (2013) Gunshot fatalities: correlation between post-mortem multi-slice computed tomography and autopsy findings: a 30-months retrospective study. Leg Med (Tokyo) 15(3):145–148
Smith AS, Hurst GC, Duerk JL, Diaz PJ (1991) MR of ballistic materials: imaging artifacts and potential hazards. AJNR Am J Neuroradiol 12(3):567–572
pubmed: 2058521
Tuchtan L, Gorincour G, Kolopp M, Massiani P, Léonetti G, Piercecchi-Marti MD, Bartoli C (2017) Combined use of postmortem 3D computed tomography reconstructions and 3D-design software for postmortem ballistic analysis. Diagn Interv Imaging 98(11):809–812
pubmed: 28739434
Yen K, Lövblad KO, Scheurer E, Ozdoba C, Thali MJ, Aghayev E, Jackowski C, Anon J, Frickey N, Zwygart K, Weis J, Dirnhofer R (2007) Post-mortem forensic neuroimaging: correlation of MSCT and MRI findings with autopsy results. Forensic Sci Int 173(1):21–35
pubmed: 17336008
Sano R, Hirawasa S, Kobayashi S, Shimada T, Awata S, Takei H, Otake H, Takahashi K, Takahashi Y, Kominato Y (2011) Use of postmortem computed tomography to reveal an intraoral gunshot injuries in a charred body. Leg Med (Tokyo) 13(6):286–288
Viel G, Gehl A, Sperhake JP (2009) Intersecting fractures of the skull and gunshot wounds. Case report and literature review. Forensic Sci Med Pathol 5(1):22–27
pubmed: 19291431
Berens S, Ketterer T, Kneubuehl BP, Thali MJ, Ross S, Bolliger SA (2011) A case of homicidal intraoral gunshot and review of the literature. Forensic Sci Med Pathol 7(2):209–212
pubmed: 21076946
McLaughlin S, Bouhaidar R (2015) Post-mortem CT appearances in pulmonary blast injury secondary to shotgun suicide. J Forensic Radiol Imaging 3(2):131–133
Schyma C, Placidi P, Schild HH (1996) Radiological findings in gunshot wounds caused by hunting ammunition. An experimental study. Int J Legal Med 108(4):201–205
pubmed: 8652425
Fais P, Giraudo C, Boscolo-Berto R, Amagliani A, Miotto D, Feltrin G, Viel G, Ferrara SD, Cecchetto G (2013) Micro-CT features of intermediate gunshot wounds severely damaged by fire. Int J Legal Med 127(2):419–425
pubmed: 23010908
Fais P, Giraudo C, Viero A, Amagliani A, Viel G, Montisci M, Miotto D, Cecchetto G (2015) Identification of bullet entrance in different type of intermediate firearm wounds through micro-computed tomography analysis. J Forensic Radiol Imaging 3(3):147–152
Amadasi A, Borgonovo S, Brandone A, Di Giancamillo M, Cattaneo C (2012) The survival of metallic residues from gunshot wounds in cremated bone: a radiological study. Int J Legal Med 126(3):363–369
pubmed: 22037901
Amadasi A, Borgonovo S, Brandone A, Di Giancamillo M, Cattaneo C (2014) A comparison between digital radiography, computed tomography, and magnetic resonance in the detection of gunshot residues in burnt tissues and bone. J Forensic Sci 59(3):712–717
pubmed: 24147424
Tartaglione T, Filograna L, Roiati S, Guglielmi G, Colosimo C, Bonomo L (2012) Importance of 3D-CT imaging in single-bullet cranioencephalic gunshot wounds. Radiol Med 117(3):461–470
pubmed: 22271006
Thali MJ, Kneubuehl BP, Vock P, G v A, Dirnhofer R (2002) High-speed documented experimental gunshot to a skull-brain model and radiologic virtual autopsy. Am J Forensic Med Pathol 23(3):223–228
pubmed: 12198345
Oehmichen M, Meissner C, König HG, Gehl H-BB (2004) Gunshot injuries to the head and brain caused by low-velocity handguns and rifles. A review. Forensic Sci Int 146(2–3):111–120
pubmed: 15542271
Smith OC, Berryman HE, Symes SA, Francisco JT, Hnilica V (1993) Atypical gunshot exit defects to the cranial vault. J Forensic Sci 38(2):339–334
pubmed: 8454994
Delannoy Y, Colard T, Le Garff E, Humez S, Gosset D, Hedouin V (2016) The mechanism of the keyhole lesion reassessed: an experimental approach. J Forensic Legal Med 37:1–7
Abdul Rashid SN, Martinez RM, Ampanozi, Thali MJ, Bartsch (2013) A rare case of suicide by gunshot with nasal entry assessed by classical autopsy, post-mortem computed tomography (PMCT) and post-mortem magnetic resonance imaging (PMMR). J Forensic Radiol Imaging 1(2):63–67
Verhoff MA, Karger B, Ramsthaler F, Obert M (2008) Investigations on an isolated skull with gunshot wounds using flat-panel CT. Int J Legal Med 122(5):441–445
pubmed: 18581128
Lantz PE, Jerome WG, Jaworski JA (1994) Radiopaque deposits surrounding a contact small-caliber gunshot wound. Am J Forensic Med Pathol 15(1):10–13
pubmed: 8166107
Stein KM, Bahner ML, Merkel J, Ain S, Mattern R (2000) Detection of gunshot residues in routine CTs. Int J Legal Med 114(1–2):15–18
pubmed: 11197621
Oehmichen M, Meissner C (2009) Routine techniques in forensic neuropathology as demonstrated by gunshot injury to the head. Leg Med (Tokyo) 11 Suppl 1:S50–S53
Cecchetto G, Amagliani A, Giraudo C, Fais P, Cavarzeran F, Montisci M, Feltrin G, Viel G, Ferrara SD (2012) Micro-CT detection of gunshot residue in fresh and decomposed firearm wounds. Int J Legal Med 126(3):377–383
pubmed: 22086714
Giraudo C, Fais P, Pelletti G, Viero A, Miotto D, Boscolo-Berto R, Viel G, Montisci M, Cecchetto G, Ferrara SD (2016) Micro-CT features of intermediate gunshot wounds covered by textiles. Int J Legal Med 130(5):1257–1264
pubmed: 27325255
Colard T, Delannoy Y, Bresson F, Marechal C, Raul JS, Hedouin V (2013) 3D-MSCT imaging of bullet trajectory in 3D crime scene reconstruction: two case reports. Leg Med (Tokyo) 15(6):318–322
Thali MJ, Schweitzer W, Yen K, Vock P, Ozdoba C, Spielvogel E, Dirnhofer R (2003) New horizons in forensic radiology: the 60-second digital autopsy-full-body examination of a gunshot victim by multislice computed tomography. Am J Forensic Med Pathol 24(1):22–27
pubmed: 12604993
Lancia M, Rosati V, Gioia S, Conforti F, Suadoni F (2014) An unusual case of unintentional firearm death of a 3-year-old child. Am J Forensic Med Pathol 35(3):178–180
pubmed: 25051195
Gibb IE (2008) Computed tomography of projectile injuries. Clin Radiol 63(10):1167–1168
pubmed: 18774365
Hayashi T, Gapert R, Tsokos M, Hartwig S (2013) Suicide with two shots to the head using a rare ‘Velo-Dog’ pocket revolver. Forensic Sci Med Pathol 9(2):265–269
Deyle S, Exadaktylos AK, Kneubuehl BP, Buck U, Thali MJ, Voisard MX (2011) Collateral damage--penetrating head injury and orbital injury: a case report. Am J Forensic Med Pathol 32(3):215–218
Malbranque S, Jousset N, Nedelcu C, Rougé-Maillart C (2014) Bone-patch type secondary projectiles: a report on two shots fired at point-blank range using hollow point bullets. Forensic Sci Int 245:e6–e10
Marchetti D, Tartaglione T, Mattiu G, Giovine E, Fiori A (2003) Reconstruction of the angle of shot by using computed radiography of the head. Am J Forensic Med Pathol 24(2):155–159
pubmed: 12773852
Straathof D, Bannach BG, Wilson AJ, Dowling GP (2000) Radiography of perforating centerfire rifle wounds of the trunk. J Forensic Sci 45(3):597–601
pubmed: 10855964
Folio LR, Fischer T, Shogan P, Frew M, Dwyer A, Provenzale JM (2011) Blast and ballistic trajectories in combat casualties: a preliminary analysis using a Cartesian positioning system with MDCT. AJR Am J Roentgenol 197(2):W233–W240
pubmed: 21785047
Folio LR, Fischer TV, Shogan PJ, Frew MI, Kang PS, Bunger R, Provenzale JM (2011) CT-based ballistic wound path identification and trajectory analysis in anatomic ballistic phantoms. Radiology 258(3):923–929
pubmed: 21224425
Filograna L, Tartaglione T, Filograna E, Cittadini F, Oliva A, Pascali VL (2010) Computed tomography (CT) virtual autopsy and classical autopsy discrepancies: radiologist’s error or a demonstration of post-mortem multi-detector computed tomography (MDCT) limitation? Forensic Sci Int 195(1–3):e13–e17
pubmed: 19954903
Harcke HT, Levy AD, Getz JM, Robinson SR (2008) MDCT analysis of projectile injury in forensic investigation. AJR Am J Roentgenol 190(2):W106–W111
pubmed: 18212191
Peschel O, Szeimies U, Vollmar C, Kirchhoff S (2013) Postmortem 3-D reconstruction of skull gunshot injuries. Forensic Sci Int 233(1–3):45–45
pubmed: 24314500
Cascini F, Tartaglione T, Oliva A, Marchetti D (2009) A case of hunting death due to an overpenetrated bullet. Int J Legal Med 123(2):151–153
pubmed: 18682968
Choi CH, Pritchard J, Richard J (1990) Path of bullet and injuries determined by radiography. Am J Forensic Med Pathol 11(3):244–245
Le Blanc-Louvry I, Thureau S, Duval C, Papin-Lefebvre F, Thiebot J, Dacher JN, Gricourt C, Touré E, Proust B (2013) Post-mortem computed tomography compared to forensic autopsy findings: a French experience. Eur Radiol 23(7):1829–1835
pubmed: 23479220
Ruder TD, Ross S, Preiss U, Thali MJ (2010) Minimally invasive post-mortem CT-angiography in a case involving a gunshot wound. Leg Med (Tokyo) 12(3):154–156
Rutty GN, Boyce P, Robinson CE, Jeffery AJ, Morgan B (2008) The role of computed tomography in terminal ballistic analysis. Int J Legal Med 122(1):1–5
Cecchetto G, Giraudo C, Amagliani A, Viel G, Fais P, Cavarzeran F, Feltrin G, Ferrara SD, Montisci M (2011) Estimation of the firing distance through micro-CT analysis of gunshot wounds. Int J Legal Med 125(2):245–251
pubmed: 21120514

Auteurs

Arianna Giorgetti (A)

Department of Legal and Occupational Medicine, Toxicology and Public Health, University of Padova, Via Falloppio 50, 35121, Padova, Italy.

Chiara Giraudo (C)

Institute of Radiology, Department of Medicine (DiMED), University-Hospital Padova, Via Giustiniani 2, 35128, Padova, Italy.

Alessia Viero (A)

Department of Legal and Occupational Medicine, Toxicology and Public Health, University of Padova, Via Falloppio 50, 35121, Padova, Italy.

Marco Bisceglia (M)

Department of Legal and Occupational Medicine, Toxicology and Public Health, University of Padova, Via Falloppio 50, 35121, Padova, Italy.

Amalia Lupi (A)

Institute of Radiology, Department of Medicine (DiMED), University-Hospital Padova, Via Giustiniani 2, 35128, Padova, Italy.

Paolo Fais (P)

DIMEC, Department of Medical and Surgical Sciences, University of Bologna, 40126, Bologna, Italy.

Emilio Quaia (E)

Institute of Radiology, Department of Medicine (DiMED), University-Hospital Padova, Via Giustiniani 2, 35128, Padova, Italy.

Massimo Montisci (M)

Department of Legal and Occupational Medicine, Toxicology and Public Health, University of Padova, Via Falloppio 50, 35121, Padova, Italy.

Giovanni Cecchetto (G)

Department of Legal and Occupational Medicine, Toxicology and Public Health, University of Padova, Via Falloppio 50, 35121, Padova, Italy.

Guido Viel (G)

Department of Legal and Occupational Medicine, Toxicology and Public Health, University of Padova, Via Falloppio 50, 35121, Padova, Italy. guido.viel@unipd.it.

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