Intrinsically aggregation-prone proteins form amyloid-like aggregates and contribute to tissue aging in
C. elegans
aging
amyloid
cell biology
molecular biophysics
protein aggregation
structural biology
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
03 05 2019
03 05 2019
Historique:
received:
22
10
2018
accepted:
02
05
2019
pubmed:
3
5
2019
medline:
26
2
2020
entrez:
4
5
2019
Statut:
epublish
Résumé
Reduced protein homeostasis leading to increased protein instability is a common molecular feature of aging, but it remains unclear whether this is a cause or consequence of the aging process. In neurodegenerative diseases and other amyloidoses, specific proteins self-assemble into amyloid fibrils and accumulate as pathological aggregates in different tissues. More recently, widespread protein aggregation has been described during normal aging. Until now, an extensive characterization of the nature of age-dependent protein aggregation has been lacking. Here, we show that age-dependent aggregates are rapidly formed by newly synthesized proteins and have an amyloid-like structure resembling that of protein aggregates observed in disease. We then demonstrate that age-dependent protein aggregation accelerates the functional decline of different tissues in
Identifiants
pubmed: 31050339
doi: 10.7554/eLife.43059
pii: 43059
pmc: PMC6524967
doi:
pii:
Substances chimiques
Amyloid
0
Caenorhabditis elegans Proteins
0
Protein Aggregates
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Medical Research Council
ID : MR/K02292X/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N012453/1
Pays : United Kingdom
Organisme : NIH HHS
ID : P40 OD010440
Pays : United States
Organisme : Medical Research Council
ID : MC_G1000734
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/R021805/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/P027431/1
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/H023917/1
Pays : United Kingdom
Informations de copyright
© 2019, Huang et al.
Déclaration de conflit d'intérêts
CH, SW, AS, RJ, CP, TS, ML, NS, ML, RL, CM, MV, CK, GK, DD No competing interests declared
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