The Trifluoromethyl Group as a Bioisosteric Replacement of the Aliphatic Nitro Group in CB
Allosteric Regulation
/ drug effects
Animals
Behavior, Animal
/ drug effects
Binding Sites
Cyclic AMP
/ metabolism
Drug Design
Isomerism
Ligands
Male
Mice
Mice, Inbred C57BL
Models, Molecular
Neuralgia
/ drug therapy
Nitro Compounds
/ chemical synthesis
Receptor, Cannabinoid, CB1
/ drug effects
Small Molecule Libraries
Structure-Activity Relationship
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
23 05 2019
23 05 2019
Historique:
pubmed:
6
5
2019
medline:
17
6
2020
entrez:
4
5
2019
Statut:
ppublish
Résumé
The first generation of CB
Identifiants
pubmed: 31050898
doi: 10.1021/acs.jmedchem.9b00252
pmc: PMC7871173
mid: NIHMS1553182
doi:
Substances chimiques
Ligands
0
Nitro Compounds
0
Receptor, Cannabinoid, CB1
0
Small Molecule Libraries
0
Cyclic AMP
E0399OZS9N
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5049-5062Subventions
Organisme : NIDA NIH HHS
ID : P30 DA033934
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA039942
Pays : United States
Organisme : CIHR
ID : PP2-139101
Pays : Canada
Organisme : CIHR
ID : PPP-125784
Pays : Canada
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