Channeled ECM-Based Nanofibrous Hydrogel for Engineering Vascularized Cardiac Tissues.
ECM-based hydrogels
cardiac tissue engineering
vascularization
Journal
Nanomaterials (Basel, Switzerland)
ISSN: 2079-4991
Titre abrégé: Nanomaterials (Basel)
Pays: Switzerland
ID NLM: 101610216
Informations de publication
Date de publication:
02 May 2019
02 May 2019
Historique:
received:
18
03
2019
revised:
22
04
2019
accepted:
26
04
2019
entrez:
5
5
2019
pubmed:
6
5
2019
medline:
6
5
2019
Statut:
epublish
Résumé
Hydrogels are widely used materials for cardiac tissue engineering. However, once the cells are encapsulated within hydrogels, mass transfer to the core of the engineered tissue is limited, and cell viability is compromised. Here, we report on the development of a channeled ECM-based nanofibrous hydrogel for engineering vascularized cardiac tissues. An omentum hydrogel was mixed with cardiac cells, patterned to create channels and closed, and then seeded with endothelial cells to form open cellular lumens. A mathematical model was used to evaluate the necessity of the channels for maintaining cell viability and the true potential of the vascularized hydrogel to form a viable cardiac patch was studied.
Identifiants
pubmed: 31052595
pii: nano9050689
doi: 10.3390/nano9050689
pmc: PMC6566362
pii:
doi:
Types de publication
Journal Article
Langues
eng
Déclaration de conflit d'intérêts
The authors declare no conflict of interest
Références
Chem Rev. 2001 Jul;101(7):1869-79
pubmed: 11710233
Biomaterials. 2003 Nov;24(24):4337-51
pubmed: 12922147
Nat Biotechnol. 2005 Jul;23(7):821-3
pubmed: 16003365
Neuro Oncol. 2005 Oct;7(4):452-64
pubmed: 16212810
Biotechnol Bioeng. 2006 Feb 5;93(2):332-43
pubmed: 16270298
Proc Natl Acad Sci U S A. 1926 Mar;12(3):207-14
pubmed: 16576980
Microvasc Res. 2006 May;71(3):185-96
pubmed: 16600313
Lab Chip. 2007 Jun;7(6):756-62
pubmed: 17538718
Nat Mater. 2007 Nov;6(11):908-15
pubmed: 17906630
Biomaterials. 2008 Apr;29(11):1630-7
pubmed: 18201760
Tissue Eng Part B Rev. 2008 Jun;14(2):149-65
pubmed: 18498217
Trends Biotechnol. 2008 Aug;26(8):434-41
pubmed: 18585808
Biotechnol Bioeng. 1996 May 20;50(4):357-64
pubmed: 18626984
Biofabrication. 2010 Jun;2(2):022001
pubmed: 20811127
Acta Biomater. 2011 Mar;7(3):1040-9
pubmed: 20932943
Adv Drug Deliv Rev. 2011 Apr 30;63(4-5):300-11
pubmed: 21396416
Tissue Eng Part A. 2011 Nov;17(21-22):2583-92
pubmed: 21883047
J Am Coll Cardiol. 2012 Feb 21;59(8):751-63
pubmed: 22340268
Biomaterials. 2012 May;33(15):3824-34
pubmed: 22365811
Biomaterials. 2012 Sep;33(26):6020-41
pubmed: 22681979
Nat Mater. 2012 Sep;11(9):768-74
pubmed: 22751181
Biomaterials. 2012 Oct;33(29):7028-38
pubmed: 22789723
Biomaterials. 2013 Jan;34(4):1033-40
pubmed: 23158935
Tissue Eng Part C Methods. 2013 Sep;19(9):730-7
pubmed: 23320912
Lab Chip. 2013 Apr 21;13(8):1489-500
pubmed: 23440068
Annu Rev Biomed Eng. 2013;15:177-200
pubmed: 23642245
Adv Mater. 2014 May 21;26(19):3124-30
pubmed: 24550124
Nat Commun. 2014 Jun 02;5:3935
pubmed: 24887553
Biomed Mater. 2015 May 13;10(3):034106
pubmed: 25970726
Sci Adv. 2015 Oct 23;1(9):e1500758
pubmed: 26601312
Adv Healthc Mater. 2016 Apr 6;5(7):781-5
pubmed: 26844941
Nat Mater. 2016 Jun;15(6):669-78
pubmed: 26950595
Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):3179-84
pubmed: 26951646
Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):3215-20
pubmed: 26951667
Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):1898-1903
pubmed: 28167795
Adv Mater. 2019 Jan;31(1):e1803895
pubmed: 30406960
Biotechnol Adv. 2019 Feb 20;:null
pubmed: 30794878
Adv Sci (Weinh). 2019 Apr 15;6(11):1900344
pubmed: 31179230