Dopaminergic Vulnerability in Parkinson Disease: The Cost of Humans' Habitual Performance.
Parkinson disease
dopamine
goal-directed behavior
habitual behavior
vulnerability
Journal
Trends in neurosciences
ISSN: 1878-108X
Titre abrégé: Trends Neurosci
Pays: England
ID NLM: 7808616
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
12
10
2018
revised:
21
01
2019
accepted:
19
03
2019
pubmed:
6
5
2019
medline:
22
9
2020
entrez:
5
5
2019
Statut:
ppublish
Résumé
Humans can simultaneously combine automatic/habitual and voluntary/goal-directed aspects of behavioral control. Habitual routines permit us to perform well practiced task-components with minimal or no voluntary attention. Evidence from animal and human investigations indicates that dopaminergic neurons in lateral substantia nigra, which innervate the sensorimotor striatum, are engaged during the acquisition and performance of automatized skills and habits. Typically, in Parkinson disease (PD), there is a differential loss of dopamine, which occurs earliest and most severely in the caudal sensorimotor striatum, a subdivision of the striatum implicated in habitual control. We suggest that frequent reliance on habitual performance may be a critical functional stressor, which, when combined with other more general risk factors, could explain the selective neurodegeneration of the nigrostriatal motor projection in PD.
Identifiants
pubmed: 31053241
pii: S0166-2236(19)30041-4
doi: 10.1016/j.tins.2019.03.007
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
375-383Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.