Stromal cells maintain immune cell homeostasis in adipose tissue via production of interleukin-33.
Adoptive Transfer
Animals
Diet, High-Fat
/ adverse effects
Eosinophils
/ immunology
Epithelial Cells
/ immunology
Homeostasis
/ immunology
Inflammation
/ immunology
Interleukin-33
/ genetics
Intra-Abdominal Fat
/ immunology
Male
Mesenchymal Stem Cells
/ immunology
Mice
Mice, Inbred C57BL
Mice, Knockout
Obesity
/ etiology
T-Lymphocytes, Regulatory
/ immunology
Journal
Science immunology
ISSN: 2470-9468
Titre abrégé: Sci Immunol
Pays: United States
ID NLM: 101688624
Informations de publication
Date de publication:
03 05 2019
03 05 2019
Historique:
received:
16
02
2019
accepted:
03
04
2019
entrez:
5
5
2019
pubmed:
6
5
2019
medline:
6
5
2020
Statut:
ppublish
Résumé
Obesity is driven by chronic low-grade inflammation resulting from dysregulated immune cell accumulation and function in white adipose tissue (WAT). Interleukin-33 (IL-33) is a key cytokine that controls innate and adaptive immune cell activity and immune homeostasis in WAT, although the sources of IL-33 have remained controversial. Here, we show that WAT-resident mesenchyme-derived stromal cells are the dominant producers of IL-33. Adipose stem and progenitor cells (ASPCs) produced IL-33 in all WAT depots, whereas mesothelial cells served as an additional source of IL-33 in visceral WAT. ASPC-derived IL-33 promoted a regulatory circuit that maintained an immune tone in WAT via the induction of group 2 innate lymphoid cell-derived type 2 cytokines and maintenance of eosinophils, whereas mesothelial IL-33 also acted as an alarmin by inducing peritoneal immune response upon infection. Together, these data reveal a previously unrecognized regulatory network between tissue-resident progenitor cells and innate lymphoid cells that maintains immune homeostasis in adipose tissue.
Identifiants
pubmed: 31053655
pii: 4/35/eaax0416
doi: 10.1126/sciimmunol.aax0416
pmc: PMC6766755
mid: NIHMS1051013
pii:
doi:
Substances chimiques
Il33 protein, mouse
0
Interleukin-33
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : R01 AI074878
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI095466
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI106697
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI105839
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK126871
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI102942
Pays : United States
Organisme : NIAID NIH HHS
ID : R56 AI105839
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI095608
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
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