Synthesis, antimicrobial, antioxidant, cytotoxic, antiurease and molecular docking studies of N-(3-trifluoromethyl)benzoyl-N'-aryl thiourea derivatives.
Animals
Anti-Bacterial Agents
/ chemical synthesis
Antifungal Agents
/ chemical synthesis
Antineoplastic Agents
/ chemical synthesis
Antioxidants
/ chemical synthesis
Bacteria
/ drug effects
Candida
/ drug effects
Cell Line, Tumor
Cell Proliferation
/ drug effects
Drug Screening Assays, Antitumor
Enzyme Inhibitors
/ chemical synthesis
Humans
Mice
Microbial Sensitivity Tests
Molecular Docking Simulation
Molecular Structure
NIH 3T3 Cells
Oxidative Stress
/ drug effects
Thiourea
/ analogs & derivatives
Urease
/ antagonists & inhibitors
Antimicrobial
Antiurease
Cytotoxic
MRSA
Molecular docking
Oxidative burst assay
Thiourea
Journal
Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
22
01
2019
revised:
19
04
2019
accepted:
20
04
2019
pubmed:
6
5
2019
medline:
23
9
2020
entrez:
5
5
2019
Statut:
ppublish
Résumé
An irrefutable advancement has been noted for the infectious diseases caused due to ureolytic bacteria through the development of various drugs. Keeping in mind the extremely valuable synthetic utility and medicinal significance of thiourea derivatives, synthesis of new 3-trifluoromethyl benzoic acid thiourea derivatives (3a-j) were carried out. The biological potential of all compounds in terms of antimicrobial, antioxidant, cytotoxic and antiurease activities were studied. The compounds 3a, 3c and 3i with dichloro and methoxy groups substitution on the aryl group showed significant activity against all strain of bacteria while moderate to no activity was observed in remaining compounds. Whereas the antifungal evaluation showed that all compounds were active againts C. Albican and no activity was observed against C. Prapsilosis. The cytotoxic findings revealed the non-toxic nature of these compounds as IC
Identifiants
pubmed: 31054433
pii: S0045-2068(19)30112-9
doi: 10.1016/j.bioorg.2019.102946
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Antifungal Agents
0
Antineoplastic Agents
0
Antioxidants
0
Enzyme Inhibitors
0
Urease
EC 3.5.1.5
Thiourea
GYV9AM2QAG
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
102946Informations de copyright
Copyright © 2019. Published by Elsevier Inc.