Future research trends in understanding the mechanisms underlying allergic diseases for improved patient care.
Allergens
/ immunology
Disease Susceptibility
Environment
Environmental Exposure
Health Services Needs and Demand
Host-Pathogen Interactions
Humans
Hypersensitivity
/ diagnosis
Immune Tolerance
Immunomodulation
Inflammation
/ complications
Neuroimmunomodulation
Patient Care
/ standards
Precision Medicine
Quality Improvement
Research
/ trends
allergy
exposome
microbiome
neuroimmune
respiratory viral infections
Journal
Allergy
ISSN: 1398-9995
Titre abrégé: Allergy
Pays: Denmark
ID NLM: 7804028
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
21
02
2019
revised:
28
03
2019
accepted:
12
04
2019
pubmed:
6
5
2019
medline:
10
9
2020
entrez:
7
5
2019
Statut:
ppublish
Résumé
The specialties of allergy and clinical immunology have entered the era of precision medicine with the stratification of diseases into distinct disease subsets, specific diagnoses, and targeted treatment options, including biologicals and small molecules. This article reviews recent developments in research and patient care and future trends in the discipline. The section on basic mechanisms of allergic diseases summarizes the current status and defines research needs in structural biology, type 2 inflammation, immune tolerance, neuroimmune mechanisms, role of the microbiome and diet, environmental factors, and respiratory viral infections. In the section on diagnostic challenges, clinical trials, precision medicine and immune monitoring of allergic diseases, asthma, allergic and nonallergic rhinitis, and new approaches to the diagnosis and treatment of drug hypersensitivity reactions are discussed in further detail. In the third section, unmet needs and future research areas for the treatment of allergic diseases are highlighted with topics on food allergy, biologics, small molecules, and novel therapeutic concepts in allergen-specific immunotherapy for airway disease. Unknowns and future research needs are discussed at the end of each subsection.
Identifiants
pubmed: 31056763
doi: 10.1111/all.13851
pmc: PMC6973012
doi:
Substances chimiques
Allergens
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2293-2311Informations de copyright
© 2019 The Authors Allergy Published by John Wiley & Sons Ltd.
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