Genetic Regulation of Liver Metabolites and Transcripts Linking to Biochemical-Clinical Parameters.
SNPs
biochemical-clinical traits
biomarker
eQTL
mQTL
metabolite
pig model
transcript
Journal
Frontiers in genetics
ISSN: 1664-8021
Titre abrégé: Front Genet
Pays: Switzerland
ID NLM: 101560621
Informations de publication
Date de publication:
2019
2019
Historique:
received:
15
11
2018
accepted:
01
04
2019
entrez:
7
5
2019
pubmed:
7
5
2019
medline:
7
5
2019
Statut:
epublish
Résumé
Given the central metabolic role of the liver, hepatic metabolites and transcripts reflect the organismal physiological state. Biochemical-clinical plasma biomarkers, hepatic metabolites, transcripts, and single nucleotide polymorphism (SNP) genotypes of some 300 pigs were integrated by weighted correlation networks and genome-wide association analyses. Network-based approaches of transcriptomic and metabolomics data revealed linked of transcripts and metabolites of the pentose phosphate pathway (PPP). This finding was evidenced by using a NADP/NADPH assay and
Identifiants
pubmed: 31057604
doi: 10.3389/fgene.2019.00348
pmc: PMC6478805
doi:
Types de publication
Journal Article
Langues
eng
Pagination
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