Real-time Video Projection in an MRI for Characterization of Neural Correlates Associated with Mirror Therapy for Phantom Limb Pain.
Journal
Journal of visualized experiments : JoVE
ISSN: 1940-087X
Titre abrégé: J Vis Exp
Pays: United States
ID NLM: 101313252
Informations de publication
Date de publication:
20 04 2019
20 04 2019
Historique:
entrez:
7
5
2019
pubmed:
7
5
2019
medline:
13
3
2020
Statut:
epublish
Résumé
Mirror therapy (MT) has been proposed as an effective rehabilitative strategy to alleviate pain symptoms in amputees with phantom limb pain (PLP). However, establishing the neural correlates associated with MT therapy have been challenging given that it is difficult to administer the therapy effectively within a magnetic resonance imaging (MRI) scanner environment. To characterize the functional organization of cortical regions associated with this rehabilitative strategy, we have developed a combined behavioral and functional neuroimaging protocol that can be applied in participants with a leg amputation. This novel approach allows participants to undergo MT within the MRI scanner environment by viewing real-time video images captured by a camera. The images are viewed by the participant through a system of mirrors and a monitor that the participant views while lying on the scanner bed. In this manner, functional changes in cortical areas of interest (e.g., sensorimotor cortex) can be characterized in response to the direct application of MT.
Identifiants
pubmed: 31058883
doi: 10.3791/58800
pmc: PMC6510542
mid: NIHMS1020907
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Video-Audio Media
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NICHD NIH HHS
ID : R01 HD082302
Pays : United States
Références
J Anaesthesiol Clin Pharmacol. 2015 Oct-Dec;31(4):575-8
pubmed: 26702228
Disabil Rehabil. 2002 Jun 15;24(9):462-70
pubmed: 12097215
Ann Transl Med. 2016 Dec;4(23):454
pubmed: 28090510
Trends Cogn Sci. 2013 Jul;17(7):307-8
pubmed: 23608362
Int J Rehabil Res. 2011 Mar;34(1):1-13
pubmed: 21326041
Neurosci Lett. 1997 Mar 7;224(1):5-8
pubmed: 9132689
Mem Cognit. 1974 Mar;2(2):329-36
pubmed: 24214763
JMIR Res Protoc. 2016 Jul 06;5(3):e138
pubmed: 27383993
Pain. 2010 May;149(2):296-304
pubmed: 20359825
Korean J Pain. 2012 Oct;25(4):272-4
pubmed: 23091690
Scand J Pain. 2017 Apr;15:98-103
pubmed: 28850360
Brain Res. 2015 Jan 12;1594:173-82
pubmed: 25446453
Pain. 1997 Dec;73(3):413-21
pubmed: 9469533
Stud Health Technol Inform. 1998;58:63-6
pubmed: 10350929
Magn Reson Med. 1995 May;33(5):636-47
pubmed: 7596267
Neurol Clin. 1998 Nov;16(4):919-36
pubmed: 9767070
J Rehabil Med. 2012 Mar;44(3):254-60
pubmed: 22378591
Rehabil Psychol. 2016 Nov;61(4):358-370
pubmed: 27709978
J Neurosci. 1996 Jul 1;16(13):4207-21
pubmed: 8753882
Pain Res Treat. 2011;2011:864605
pubmed: 22110933
Front Neurol. 2018 Feb 19;9:67
pubmed: 29515513
Neuroreport. 1994 Dec 20;5(18):2593-7
pubmed: 7696611
BMJ. 1999 Sep 4;319(7210):587-8
pubmed: 10473458
Brain. 2001 Nov;124(Pt 11):2268-77
pubmed: 11673327
Front Behav Neurosci. 2015 Aug 10;9:212
pubmed: 26321933
Neuroimage. 2012 Aug 15;62(2):782-90
pubmed: 21979382
Ann Clin Transl Neurol. 2016 May 11;3(6):463-4
pubmed: 27547774
Exp Brain Res. 2015 Jun;233(6):1921-9
pubmed: 25850405
Neuroimage. 2006 Jul 1;31(3):968-80
pubmed: 16530430
Nat Rev Neurosci. 2006 Nov;7(11):873-81
pubmed: 17053811
Neuroimage. 2004;23 Suppl 1:S208-19
pubmed: 15501092
Front Comput Neurosci. 2016 Jun 28;10:66
pubmed: 27445782
Clin J Pain. 2003 Jan-Feb;19(1):18-30
pubmed: 12514453
J Neuroeng Rehabil. 2015 Aug 02;12:63
pubmed: 26233677
Hum Brain Mapp. 2014 May;35(5):1981-96
pubmed: 23861343
JMIR Serious Games. 2017 Aug 07;5(3):e15
pubmed: 28784593
N Engl J Med. 2007 Nov 22;357(21):2206-7
pubmed: 18032777
Neurology. 2006 Apr 25;66(8):1241-4
pubmed: 16636242
Nat Commun. 2013;4:1570
pubmed: 23463013
Eur J Pain. 2014 May;18(5):729-39
pubmed: 24327313
Ann Clin Transl Neurol. 2014 Sep;1(9):633-8
pubmed: 25493277
Nature. 1995 Jun 8;375(6531):482-4
pubmed: 7777055