Experiencing community and domestic violence is associated with epigenetic changes in DNA methylation of BDNF and CLPX in adolescents.
Adolescent
Adult
Aged
Aged, 80 and over
Brain-Derived Neurotrophic Factor
/ genetics
Child
DNA Methylation
/ genetics
Domestic Violence
Endopeptidase Clp
/ genetics
Epigenesis, Genetic
/ genetics
Exposure to Violence
Female
Grandparents
Humans
Male
Middle Aged
Mothers
Residence Characteristics
Survivors
Young Adult
BDNF
DNA methylation
adolescents
epigenetics
intergenerational
violence
Journal
Psychophysiology
ISSN: 1540-5958
Titre abrégé: Psychophysiology
Pays: United States
ID NLM: 0142657
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
30
05
2018
revised:
03
04
2019
accepted:
04
04
2019
pubmed:
7
5
2019
medline:
7
1
2021
entrez:
7
5
2019
Statut:
ppublish
Résumé
Experiencing violence changes behavior, shapes personalities, and poses a risk factor for mental disorders. This association might be mediated through epigenetic modifications that affect gene expression, such as DNA methylation. The present study investigated the impact of community and domestic violence on DNA methylation measured in saliva collected from 375 individuals including three generations: grandmothers (n = 126), mothers (n = 125), and adolescents (n = 124, 53% female). Using the Infinium HumanMethylation450 BeadChip array, in adolescents, we detected two CpG sites that showed an association of DNA methylation and lifetime exposure to community and domestic violence even after FDR correction: BDNF_cg06260077 (logFC -0.454, p = 3.71E-07), and CLPX_cg01908660 (logFC = -0.372, p = 1.38E-07). Differential DNA methylation of the CpG BDNF_cg06260077 associated with exposure to violence was also observed in the maternal but not the grandmaternal generation. BDNF (brain-derived neurotrophic factor) and CLPX (caseinolytic mitochondrial matrix peptidase chaperone subunit) genes are involved in neural development. Our results thus reveal altered molecular mechanisms of developmental and intergenerational trajectories in survivors of repeated violent experiences.
Identifiants
pubmed: 31059136
doi: 10.1111/psyp.13382
pmc: PMC7003421
doi:
Substances chimiques
Brain-Derived Neurotrophic Factor
0
BDNF protein, human
7171WSG8A2
Endopeptidase Clp
EC 3.4.21.92
CLPX protein, human
EC 3.6.1.3
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13382Subventions
Organisme : European Research Council
ID : 323977
Pays : International
Informations de copyright
© 2019 The Authors Psychophysiology published by Wiley Periodicals, Inc. on behalf of Society for Psychophysiological Research.
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