Screening of the pathogen box for the identification of anti-Acanthamoeba agents.

Acanthamoeba castellanii / drug effects Amebicides / classification Animals Cell Line / drug effects Cell Survival / drug effects Dose-Response Relationship, Drug Inhibitory Concentration 50 Mice Pentamidine / pharmacology Triazoles / pharmacology Trophozoites / drug effects
Acanthamoeba castellanii Neff Amoebicidal activity Pathogen box Trophozoite

Journal

Experimental parasitology
ISSN: 1090-2449
Titre abrégé: Exp Parasitol
Pays: United States
ID NLM: 0370713

Informations de publication

Date de publication:
Jun 2019
Historique:
received: 26 01 2019
revised: 25 03 2019
accepted: 30 04 2019
pubmed: 7 5 2019
medline: 5 6 2019
entrez: 7 5 2019
Statut: ppublish

Résumé

Acanthamoeba are free living amoeba that have been isolated from different environments like soil, water, air dust. Moreover, they are also able to act as opportunist pathogens, mainly causing a fatal encephalitis and also keratitis in both human and animals. This study was aimed to evaluate the activity of the Medicines for Malaria Venture (MMV) compounds against the trophozoite stage of Acanthamoeba castellanii Neff. Sixteen compounds showed ≥90% inhibition of parasite growth in the initial screen (10 μM). Those set were further evaluated to determine the inhibitor concentration that inhibit the 50% of the initial population and cytotoxicity against murine macrophages. Among the compounds included in the pathogen box, pentamidine and posaconazole were the most effective against this parasite with an of IC

Identifiants

DOI: 10.1016/j.exppara.2019.04.013 PMID: 31059693
pubmed: 31059693
pii: S0014-4894(19)30037-2
doi: 10.1016/j.exppara.2019.04.013
pii:
doi:

Substances chimiques

Amebicides 0
Triazoles 0
Pentamidine 673LC5J4LQ
posaconazole 6TK1G07BHZ

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

90-92

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Auteurs

Ines Sifaoui (I)

University Institute of Tropical Diseases and Public Health, Universidad de La Laguna, Avda Francisco Sanchez s/n, Campus de Anchieta, 38271, la Laguna Tenerife, Canary Islands, Spain; Laboratoire Matériaux-Molécules et Applications, IPEST, B.P 51 2070, La Marsa, University of Carthage, Tunisia.

María Reyes-Batlle (M)

University Institute of Tropical Diseases and Public Health, Universidad de La Laguna, Avda Francisco Sanchez s/n, Campus de Anchieta, 38271, la Laguna Tenerife, Canary Islands, Spain.

Atteneri López-Arencibia (A)

University Institute of Tropical Diseases and Public Health, Universidad de La Laguna, Avda Francisco Sanchez s/n, Campus de Anchieta, 38271, la Laguna Tenerife, Canary Islands, Spain.

Olfa Chiboub (O)

University Institute of Tropical Diseases and Public Health, Universidad de La Laguna, Avda Francisco Sanchez s/n, Campus de Anchieta, 38271, la Laguna Tenerife, Canary Islands, Spain; Laboratoire Matériaux-Molécules et Applications, IPEST, B.P 51 2070, La Marsa, University of Carthage, Tunisia.

Carlos J Bethencourt-Estrella (CJ)

University Institute of Tropical Diseases and Public Health, Universidad de La Laguna, Avda Francisco Sanchez s/n, Campus de Anchieta, 38271, la Laguna Tenerife, Canary Islands, Spain.

Desirée San Nicolás-Hernández (D)

University Institute of Tropical Diseases and Public Health, Universidad de La Laguna, Avda Francisco Sanchez s/n, Campus de Anchieta, 38271, la Laguna Tenerife, Canary Islands, Spain.

Rubén L Rodríguez Expósito (RL)

University Institute of Tropical Diseases and Public Health, Universidad de La Laguna, Avda Francisco Sanchez s/n, Campus de Anchieta, 38271, la Laguna Tenerife, Canary Islands, Spain.

Aitor Rizo-Liendo (A)

University Institute of Tropical Diseases and Public Health, Universidad de La Laguna, Avda Francisco Sanchez s/n, Campus de Anchieta, 38271, la Laguna Tenerife, Canary Islands, Spain.

José E Piñero (JE)

University Institute of Tropical Diseases and Public Health, Universidad de La Laguna, Avda Francisco Sanchez s/n, Campus de Anchieta, 38271, la Laguna Tenerife, Canary Islands, Spain. Electronic address: jpinero@ull.edu.es.

Jacob Lorenzo-Morales (J)

University Institute of Tropical Diseases and Public Health, Universidad de La Laguna, Avda Francisco Sanchez s/n, Campus de Anchieta, 38271, la Laguna Tenerife, Canary Islands, Spain.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Amoebozoa › Lobosea › Amoebida › Acanthopodina › Acanthamoeba › Acanthamoeba castellanii › Screening of the pathogen box for the...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiparasitaires › Antiprotozoaires › Antiamibiens › Screening of the pathogen box for the...
questionsmedicales.fr › Eucaryotes › Animaux › Screening of the pathogen box for the...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Screening of the pathogen box for the...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Survie cellulaire › Screening of the pathogen box for the...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Screening of the pathogen box for the...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Concentration inhibitrice 50 › Screening of the pathogen box for the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Screening of the pathogen box for the...
questionsmedicales.fr › Composés chimiques organiques › Amidines › Benzamidines › Pentamidine › Screening of the pathogen box for the...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Triazoles › Screening of the pathogen box for the...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Morphogenèse › Métamorphose biologique › Étapes du cycle de vie › Trophozoïtes › Screening of the pathogen box for the...