Studies on vascular response to full superantigens and superantigen derived peptides: Possible production of novel superantigen variants with less vasodilation effect for tolerable cancer immunotherapy.

Animals Escherichia coli / genetics Immunotherapy Lymphocyte Activation / drug effects Muscle, Smooth, Vascular / drug effects Neoplasms / drug therapy Peptides / genetics Sheep Superantigens / genetics T-Lymphocytes / drug effects Vasodilation / drug effects
Hyperpolarization and antihypertensive drugs Hypotension Potassium channel Superantigen based peptides Superantigenicity T-cell activation Vasodilation

Journal

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
ISSN: 1950-6007
Titre abrégé: Biomed Pharmacother
Pays: France
ID NLM: 8213295

Informations de publication

Date de publication:
Jul 2019
Historique:
received: 17 02 2019
revised: 12 04 2019
accepted: 22 04 2019
pubmed: 7 5 2019
medline: 15 1 2020
entrez: 7 5 2019
Statut: ppublish

Résumé

Superantigens (SAgs) are a class of antigens that cause non-specific activation of T-cells resulting in polyclonal T cell activation and massive cytokine release and causing symptoms similar to sepsis, e.g. hypotension and subsequent hyporeactivity. We investigated the direct effect of SAgs on vascular tone using two recombinant SAgs, SEA and SPEA. The roles of Nitric Oxide (NO) and potentially hyperpolarization, which is dependent on the K

Identifiants

DOI: 10.1016/j.biopha.2019.108905 PMID: 31060004
pubmed: 31060004
pii: S0753-3322(19)30696-1
doi: 10.1016/j.biopha.2019.108905
pii:
doi:

Substances chimiques

Peptides 0
Superantigens 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

108905

Informations de copyright

Copyright © 2019 The Authors. Published by Elsevier Masson SAS.. All rights reserved.

Auteurs

Sara S Bashraheel (SS)

Protein Engineering Unit, Life and Science Research Department, Anti-Doping Lab-Qatar (ADLQ), Doha, Qatar; Drug Design Group, Department of Pharmacy, University of Groningen, Groningen, the Netherlands.

Alanod D AlQahtani (AD)

Protein Engineering Unit, Life and Science Research Department, Anti-Doping Lab-Qatar (ADLQ), Doha, Qatar; Drug Design Group, Department of Pharmacy, University of Groningen, Groningen, the Netherlands.

Fatma B Rashidi (FB)

Cairo University, Faculty of Science, Giza, Egypt.

Haya Al-Sulaiti (H)

Protein Engineering Unit, Life and Science Research Department, Anti-Doping Lab-Qatar (ADLQ), Doha, Qatar; Drug Design Group, Department of Pharmacy, University of Groningen, Groningen, the Netherlands.

Alexander Domling (A)

Drug Design Group, Department of Pharmacy, University of Groningen, Groningen, the Netherlands.

Nelson N Orie (NN)

Vascular Laboratory, Life and Science Research Department, Anti-Doping Lab-Qatar (ADLQ), Doha, Qatar.

Sayed K Goda (SK)

Protein Engineering Unit, Life and Science Research Department, Anti-Doping Lab-Qatar (ADLQ), Doha, Qatar; Cairo University, Faculty of Science, Giza, Egypt. Electronic address: sgoda@adlqatar.qa.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Studies on vascular response to full...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Escherichia › Escherichia coli › Studies on vascular response to full...
questionsmedicales.fr › Thérapeutique › Biothérapie › Immunothérapie › Studies on vascular response to full...
questionsmedicales.fr › Phénomènes du système immunitaire › Activation des lymphocytes › Studies on vascular response to full...
questionsmedicales.fr › Tissus › Muscles › Muscles lisses › Muscles lisses vasculaires › Studies on vascular response to full...
questionsmedicales.fr › Tumeurs › Studies on vascular response to full...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Studies on vascular response to full...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Ruminants › Ovis › Studies on vascular response to full...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Superantigènes › Studies on vascular response to full...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Studies on vascular response to full...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Hémodynamique › Vasodilatation › Studies on vascular response to full...