Matrix metalloproteinases as possible biomarkers of obstructive sleep apnea severity - A systematic review.

Biomarkers / metabolism Cardiovascular Diseases / etiology Humans Hypoxia / complications Matrix Metalloproteinases / metabolism Oxidative Stress / physiology Sleep Apnea, Obstructive / metabolism
Cardiovascular disease Matrix metalloproteinase Obstructive sleep apnea Oxidative stress Sleep disordered breathing Systematic review

Journal

Sleep medicine reviews
ISSN: 1532-2955
Titre abrégé: Sleep Med Rev
Pays: England
ID NLM: 9804678

Informations de publication

Date de publication:
08 2019
Historique:
received: 28 01 2019
revised: 18 03 2019
accepted: 25 03 2019
pubmed: 7 5 2019
medline: 6 5 2020
entrez: 7 5 2019
Statut: ppublish

Résumé

Obstructive sleep apnea is an underdiagnosed sleep-related breathing disorder affecting millions of people. Recurrent episodes of apnea/hypopnea result in intermittent hypoxia leading to oxidative stress. Obstructive sleep apnea is considered an independent risk factor for cardiovascular disease but the exact pathophysiology of adverse cardiovascular outcomes of obstructive sleep apnea has not been fully elucidated. Matrix metalloproteinases (MMPs) have been associated with both oxidative stress and cardiovascular diseases. Hypoxic conditions were shown to influence MMP expression, secretion and activity. Moreover, matrix metalloproteinases contribute to ischemia/reperfusion injury. Therefore, action of matrix metalloproteinases can provide a possible molecular mechanism linking obstructive sleep apnea with oxidative stress and cardiovascular disease. The aim of this paper was to review the current evidence of association between matrix metalloproteinases and obstructive sleep apnea with focus on hypoxemia and severity of obstructive sleep apnea.

Identifiants

DOI: 10.1016/j.smrv.2019.03.010 PMID: 31060030
pubmed: 31060030
pii: S1087-0792(19)30022-X
doi: 10.1016/j.smrv.2019.03.010
pii:
doi:

Substances chimiques

Biomarkers 0
Matrix Metalloproteinases EC 3.4.24.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't Systematic Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

9-16

Subventions

Organisme : CIHR
Pays : Canada

Informations de copyright

Crown Copyright © 2019. Published by Elsevier Ltd. All rights reserved.

Auteurs

Aleksandra Franczak (A)

Division of Respiratory, Critical Care and Sleep Medicine, University of Saskatchewan, Saskatoon, Canada; Department of Medical Laboratory Diagnostics, Division of Clinical Chemistry, Wroclaw Medical University, Wroclaw, Poland.

Iwona Bil-Lula (I)

Department of Medical Laboratory Diagnostics, Division of Clinical Chemistry, Wroclaw Medical University, Wroclaw, Poland.

Grzegorz Sawicki (G)

Department of Pharmacology, College of Medicine, University of Saskatchewan, Saskatoon, Canada; Department of Medical Laboratory Diagnostics, Division of Clinical Chemistry, Wroclaw Medical University, Wroclaw, Poland.

Mark Fenton (M)

Division of Respiratory, Critical Care and Sleep Medicine, University of Saskatchewan, Saskatoon, Canada; Canadian Sleep and Circadian Network.

Najib Ayas (N)

University of British Columbia, Vancouver, B.C. Canada; Canadian Sleep and Circadian Network.

Robert Skomro (R)

Division of Respiratory, Critical Care and Sleep Medicine, University of Saskatchewan, Saskatoon, Canada; Canadian Sleep and Circadian Network; Division of Angiology, Wroclaw Medical University, Wroclaw, Poland. Electronic address: r.skomro@usask.ca.

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Matrix metalloproteinases as possible...
questionsmedicales.fr › Maladies cardiovasculaires › Matrix metalloproteinases as possible...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Matrix metalloproteinases as possible...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Signes et symptômes respiratoires › Hypoxie › Matrix metalloproteinases as possible...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Metalloproteases › Metalloendopeptidases › Matrix metalloproteinases › Matrix metalloproteinases as possible...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Matrix metalloproteinases as possible...
questionsmedicales.fr › Maladies du système nerveux › Syndromes d'apnées du sommeil › Syndrome d'apnées obstructives du sommeil › Matrix metalloproteinases as possible...