Impact of taxane plus bevacizumab for ovarian sex cord tumor with annular tubules.
Peutz-Jeghers syndrome
bevacizumab
recurrence
sex cord tumor with annular tubules
taxane
Journal
The journal of obstetrics and gynaecology research
ISSN: 1447-0756
Titre abrégé: J Obstet Gynaecol Res
Pays: Australia
ID NLM: 9612761
Informations de publication
Date de publication:
Jul 2019
Jul 2019
Historique:
received:
12
11
2018
accepted:
11
04
2019
pubmed:
7
5
2019
medline:
15
1
2020
entrez:
7
5
2019
Statut:
ppublish
Résumé
Sex cord tumor with annular tubules (SCTAT) is rare, and 20% of SCTAT cases, excluding those associated with Peutz-Jeghers syndrome, are clinically malignant. Limited data is available regarding the role of chemotherapy in the management of SCTAT. We encountered a 44-year-old woman with recurrent SCTAT complicated by peritoneal dissemination following a right adnexectomy. The surgical resection could not be performed completely due to the wide extension of the tumor. Considering the potential of becoming malignant, we chose a combination of bleomycin, etoposide and cisplatin (BEP) as postoperative chemotherapy treatment. However, the patient showed partial response following a complete BEP regimen. The patient received three courses of chemotherapy with docetaxel and carboplatin plus bevacizumab. After the combination chemotherapy, positron emission tomography-computed tomography scan confirmed a complete response, and is currently continuing bevacizumab treatment without relapsing and having no major adverse effects from complications. This case proved the potential of a combination of taxane and bevacizumab in patients with recurrent SCTAT.
Substances chimiques
Bridged-Ring Compounds
0
Taxoids
0
taxane
1605-68-1
Bevacizumab
2S9ZZM9Q9V
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
1423-1428Informations de copyright
© 2019 Japan Society of Obstetrics and Gynecology.