Glomerular Hematuria: Cause or Consequence of Renal Inflammation?
AKI
chronic kidney disease (CKD)
hematuria
inflammation
oxidative stress
tubular injury
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
05 May 2019
05 May 2019
Historique:
received:
29
03
2019
revised:
21
04
2019
accepted:
28
04
2019
entrez:
8
5
2019
pubmed:
8
5
2019
medline:
23
8
2019
Statut:
epublish
Résumé
Glomerular hematuria is a cardinal symptom of renal disease. Glomerular hematuria may be classified as microhematuria or macrohematuria according to the number of red blood cells in urine. Recent evidence suggests a pathological role of persistent glomerular microhematuria in the progression of renal disease. Moreover, gross hematuria, or macrohematuria, promotes acute kidney injury (AKI), with subsequent impairment of renal function in a high proportion of patients. In this pathological context, hemoglobin, heme, or iron released from red blood cells in the urinary space may cause direct tubular cell injury, oxidative stress, pro-inflammatory cytokine production, and further monocyte/macrophage recruitment. The aim of this manuscript is to review the role of glomerular hematuria in kidney injury, the role of inflammation as cause and consequence of glomerular hematuria, and to discuss novel therapies to combat hematuria.
Identifiants
pubmed: 31060307
pii: ijms20092205
doi: 10.3390/ijms20092205
pmc: PMC6539976
pii:
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Spanish Ministry of Economy and Competitiveness
ID : RYC-2017-22369
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
Nephrol Dial Transplant. 2000 Jun;15(6):772-7
pubmed: 10831627
Blood. 2002 Jun 1;99(11):4160-5
pubmed: 12010821
Nephrol Dial Transplant. 2002 Jul;17(7):1204-11
pubmed: 12105242
N Engl J Med. 2003 Jun 5;348(23):2330-8
pubmed: 12788998
J Am Soc Nephrol. 2003 Jul;14(7 Suppl 2):S131-8
pubmed: 12819318
Arch Biochem Biophys. 1953 Jun;44(2):378-95
pubmed: 13058395
J Immunol. 2004 Aug 1;173(3):2023-30
pubmed: 15265937
Nephrol Dial Transplant. 2004 Dec;19(12):3040-9
pubmed: 15507479
Kidney Int Suppl. 2005 Apr;(94):S23-7
pubmed: 15752235
Toxicol Lett. 2005 Jul 4;157(3):175-88
pubmed: 15917143
J Am Soc Nephrol. 2007 Feb;18(2):414-20
pubmed: 17229906
Nephrology (Carlton). 2007 Jun;12(3):275-84
pubmed: 17498123
J Biol Chem. 2007 Jul 13;282(28):20221-9
pubmed: 17502383
Clin J Am Soc Nephrol. 2007 Jan;2(1):51-7
pubmed: 17699387
Pediatr Nephrol. 2009 Oct;24(10):1951-8
pubmed: 17912554
Int J Clin Pract. 2008 Mar;62(3):406-12
pubmed: 18261076
Hum Pathol. 2008 Sep;39(9):1309-16
pubmed: 18619648
Nature. 2008 Jul 24;454(7203):428-35
pubmed: 18650913
Arterioscler Thromb. 1991 Nov-Dec;11(6):1700-11
pubmed: 1931871
Nephrol Dial Transplant. 2009 Oct;24(10):3068-74
pubmed: 19515800
Am J Kidney Dis. 2009 Aug;54(2):205-26
pubmed: 19577347
Am J Kidney Dis. 2009 Dec;54(6):1121-6
pubmed: 19577348
Nephrol Dial Transplant. 2010 Feb;25(2):490-6
pubmed: 19633091
Am J Physiol Renal Physiol. 2010 Jul;299(1):F207-16
pubmed: 20410215
Nephrol Dial Transplant. 2011 May;26(5):1592-9
pubmed: 20940370
J Am Soc Nephrol. 2011 Apr;22(4):752-61
pubmed: 21258035
Kidney Int. 2011 Jul;80(2):181-9
pubmed: 21389969
J Immunol. 2011 Jun 1;186(11):6562-7
pubmed: 21536805
Pediatr Nephrol. 2012 Aug;27(8):1221-31
pubmed: 21688191
Clin Dev Immunol. 2011;2011:639074
pubmed: 21785618
JAMA. 2011 Aug 17;306(7):729-36
pubmed: 21846854
Nephrol Dial Transplant. 2012 Apr;27(4):1479-85
pubmed: 21965586
Clin J Am Soc Nephrol. 2012 Jan;7(1):175-84
pubmed: 22096039
N Engl J Med. 2011 Dec 22;365(25):2398-411
pubmed: 22187987
Nephrol Dial Transplant. 2012 Jan;27(1):28-34
pubmed: 22287699
J Nephrol. 2012 Nov-Dec;25(6):1054-9
pubmed: 22383346
N Engl J Med. 2012 Mar 22;366(12):1119-31
pubmed: 22435371
N Am J Med Sci. 2011 Apr;3(4):179-84
pubmed: 22540088
Kidney Int. 2012 Sep;82(5):548-60
pubmed: 22572859
J Immunol. 2012 Aug 15;189(4):2017-22
pubmed: 22772444
Clin J Am Soc Nephrol. 2012 Dec;7(12):1977-87
pubmed: 22977208
Nephron Clin Pract. 2012;121(1-2):c42-53
pubmed: 23095372
Am J Physiol Renal Physiol. 2013 Jun 15;304(12):F1421-7
pubmed: 23576637
Genome. 2013 Mar;56(3):161-9
pubmed: 23659700
N Engl J Med. 2013 Jun 20;368(25):2402-14
pubmed: 23782179
Nephrology (Carlton). 2013 Aug;18(8):569-75
pubmed: 23782264
Nephrol Dial Transplant. 2013 Dec;28(12):2946-60
pubmed: 24046192
Kidney Int. 2013 Dec;84(6):1079-89
pubmed: 24172683
Clin J Am Soc Nephrol. 2014 Jan;9(1):46-53
pubmed: 24178974
Blood. 2014 Jan 16;123(3):377-90
pubmed: 24277079
J Nephrol. 2015 Feb;28(1):39-49
pubmed: 24756969
Front Pharmacol. 2014 May 27;5:115
pubmed: 24904418
PLoS One. 2014 Sep 29;9(9):e108723
pubmed: 25265199
Clin Kidney J. 2014 Dec;7(6):531-7
pubmed: 25503953
J Rheumatol. 2015 Mar;42(3):437-40
pubmed: 25593226
PLoS One. 2015 May 27;10(5):e0128575
pubmed: 26016848
Sci Rep. 2015 Jun 05;5:10901
pubmed: 26045078
Case Rep Nephrol. 2015;2015:298261
pubmed: 26347498
Semin Hematol. 1989 Apr;26(2):105-13
pubmed: 2658086
Trends Mol Med. 2015 Dec;21(12):762-775
pubmed: 26614735
JAMA. 1989 Sep 1;262(9):1214-9
pubmed: 2668582
Sci Rep. 2016 Jan 28;6:19732
pubmed: 26818712
J Am Soc Nephrol. 2016 Sep;27(9):2622-9
pubmed: 26850635
Sci Rep. 2016 Mar 22;6:23498
pubmed: 27000966
Am J Clin Nutr. 1989 May;49(5):840-4
pubmed: 2718917
J Am Coll Cardiol. 2016 Nov 29;68(21):2272-2283
pubmed: 27884245
Lancet. 2017 May 27;389(10084):2117-2127
pubmed: 28363480
Front Pharmacol. 2017 Apr 04;8:146
pubmed: 28420988
J Am Soc Nephrol. 2017 Oct;28(10):3089-3099
pubmed: 28592423
J Am Soc Nephrol. 2017 Oct;28(10):2831-2834
pubmed: 28739649
Clin Exp Nephrol. 2018 Apr;22(2):299-308
pubmed: 28741050
Am J Physiol Renal Physiol. 2018 May 1;314(5):F906-F914
pubmed: 28978536
Kidney Blood Press Res. 2017;42(4):738-748
pubmed: 29050002
J Am Coll Cardiol. 2017 Nov 28;70(21):2621-2632
pubmed: 29169468
J Pathol. 2018 Mar;244(3):296-310
pubmed: 29205354
Kidney Res Clin Pract. 2017 Dec;36(4):387-392
pubmed: 29285431
J Am Coll Cardiol. 2018 Jan 16;71(2):251-252
pubmed: 29325644
Clin J Am Soc Nephrol. 2018 Feb 7;13(2):251-257
pubmed: 29371340
BMC Nephrol. 2018 Jun 26;19(1):150
pubmed: 29940877
Am J Med Sci. 2018 Sep;356(3):268-276
pubmed: 30286822
J Am Soc Nephrol. 2018 Dec;29(12):2787-2793
pubmed: 30420420
Kidney Int. 2019 Feb;95(2):268-280
pubmed: 30665568
Curr Rheumatol Rep. 2019 Feb 27;21(4):12
pubmed: 30810824
J Biol Chem. 1983 Oct 10;258(19):12069-72
pubmed: 6619154
Cancer Epidemiol Biomarkers Prev. 1994 Jul-Aug;3(5):439-43
pubmed: 7848421
Nephrol Dial Transplant. 1997 Mar;12(3):418-26
pubmed: 9075118
Proc Soc Exp Biol Med. 1997 Dec;216(3):456-63
pubmed: 9402154