Elamipretide Improves Mitochondrial Function in the Failing Human Heart.
ADP, adenosine diphosphate
BN-PAGE, blue native polyacrylamide gel electrophoresis
C, mitochondrial respiratory complex
FCCP, carbonyl cyanide p-trifluoromethoxyphenylhydrazone
HF, heart failure
RCR, respiratory control ratio
SC CCF, supercomplex coupling control factor
heart failure
high-resolution respirometry
mitochondrial-targeted compounds
supercomplex
Journal
JACC. Basic to translational science
ISSN: 2452-302X
Titre abrégé: JACC Basic Transl Sci
Pays: United States
ID NLM: 101677259
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
received:
22
10
2018
revised:
11
12
2018
accepted:
13
12
2018
entrez:
8
5
2019
pubmed:
8
5
2019
medline:
8
5
2019
Statut:
epublish
Résumé
Negative alterations of mitochondria are known to occur in heart failure (HF). This study investigated the novel mitochondrial-targeted therapeutic agent elamipretide on mitochondrial and supercomplex function in failing human hearts ex vivo. Freshly explanted failing and nonfailing ventricular tissue from children and adults was treated with elamipretide. Mitochondrial oxygen flux, complex (C) I and CIV activities, and in-gel activity of supercomplex assembly were measured. Mitochondrial function was impaired in the failing human heart, and mitochondrial oxygen flux, CI and CIV activities, and supercomplex-associated CIV activity significantly improved in response to elamipretide treatment. Elamipretide significantly improved failing human mitochondrial function.
Identifiants
pubmed: 31061916
doi: 10.1016/j.jacbts.2018.12.005
pii: S2452-302X(19)30005-1
pmc: PMC6488757
doi:
Types de publication
Journal Article
Langues
eng
Pagination
147-157Subventions
Organisme : NHLBI NIH HHS
ID : K08 HL127294
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL107715
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL126928
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001082
Pays : United States
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