Tick saliva and its role in pathogen transmission.
Borrelia burgdorferi
Ixodes ricinus
Saliva-assisted transmission
Tick-borne encephalitis virus
Vaccine
Journal
Wiener klinische Wochenschrift
ISSN: 1613-7671
Titre abrégé: Wien Klin Wochenschr
Pays: Austria
ID NLM: 21620870R
Informations de publication
Date de publication:
Apr 2023
Apr 2023
Historique:
received:
22
02
2019
accepted:
09
04
2019
medline:
24
4
2023
pubmed:
8
5
2019
entrez:
8
5
2019
Statut:
ppublish
Résumé
Tick saliva is a complex mixture of peptidic and non-peptidic molecules that aid engorgement. The composition of tick saliva changes as feeding progresses and the tick counters the dynamic host response. Ixodid ticks such as Ixodes ricinus, the most important tick species in Europe, transmit numerous pathogens that cause debilitating diseases, e.g. Lyme borreliosis and tick-borne encephalitis. Tick-borne pathogens are transmitted in tick saliva during blood feeding; however, saliva is not simply a medium enabling pathogen transfer. Instead, tick-borne pathogens exploit saliva-induced modulation of host responses to promote their transmission and infection, so-called saliva-assisted transmission (SAT). Characterization of the saliva factors that facilitate SAT is an active area of current research. Besides providing new insights into how tick-borne pathogens survive in nature, the research is opening new avenues for vaccine development.
Identifiants
pubmed: 31062185
doi: 10.1007/s00508-019-1500-y
pii: 10.1007/s00508-019-1500-y
pmc: PMC10118219
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
165-176Informations de copyright
© 2019. The Author(s).
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