Functional analysis of the latency-related gene of bovine herpesvirus types 1 and 5.
Animals
Apoptosis
/ genetics
Cattle
Cell Line
Gene Expression
Herpesviridae Infections
/ pathology
Herpesvirus 1, Bovine
/ genetics
Herpesvirus 5, Bovine
/ genetics
Host-Pathogen Interactions
/ genetics
Infectious Bovine Rhinotracheitis
/ metabolism
Meningoencephalitis
/ pathology
Neurons
/ metabolism
Protein Isoforms
/ genetics
Viral Proteins
/ genetics
Virus Activation
Virus Latency
/ genetics
Apoptosis inhibition
Bovine herpesvirus
Latency related
Neuropathogenesis
Journal
Journal of neurovirology
ISSN: 1538-2443
Titre abrégé: J Neurovirol
Pays: United States
ID NLM: 9508123
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
22
10
2018
accepted:
27
03
2019
revised:
15
03
2019
pubmed:
8
5
2019
medline:
2
10
2020
entrez:
8
5
2019
Statut:
ppublish
Résumé
Bovine herpesvirus type 1 and type 5 (BoHV-1 and BoHV-5) are two alphaherpesviruses that affect cattle with two different syndromes. While BoHV-1 mainly produces respiratory symptoms, BoHV-5 is highly neuropathogenic and responsible for meningoencephalitis in young cattle. The latency-related (LR) gene, which is not conserved between these two herpesviruses, is the only viral gene abundantly expressed in latently infected neurons. The antiapoptotic action of this gene has been demonstrated during acute infection and reactivation from latency and seems to be mainly mediated by a LR protein (ORF-2) which is truncated in amino acid 51 in the case of BoHV-5. In this work, we show that the BoHV-5 LR gene is less efficient at cell survival and apoptosis inhibition in transient as well as in established neuronal cell lines compared to its BoHV-1 homolog. We hypothesize that the BoHV-5 LR gene may have novel functions that are lacking in the BoHV-1 LR gene and that these differences may contribute to its enhanced neuropathogenesis.
Identifiants
pubmed: 31062246
doi: 10.1007/s13365-019-00745-y
pii: 10.1007/s13365-019-00745-y
doi:
Substances chimiques
Protein Isoforms
0
Viral Proteins
0
latency-related protein, Bovine herpesvirus 1
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
597-604Références
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