Arthroscopic Determination of Cartilage Proteoglycan Content and Collagen Network Structure with Near-Infrared Spectroscopy.
Arthroscopy
Deep learning
Equine
Mosaicplasty
Neural networks
Osteoarthritis
Post-traumatic osteoarthritis
Journal
Annals of biomedical engineering
ISSN: 1573-9686
Titre abrégé: Ann Biomed Eng
Pays: United States
ID NLM: 0361512
Informations de publication
Date de publication:
Aug 2019
Aug 2019
Historique:
received:
14
12
2018
accepted:
24
04
2019
pubmed:
8
5
2019
medline:
18
12
2019
entrez:
8
5
2019
Statut:
ppublish
Résumé
Conventional arthroscopic evaluation of articular cartilage is subjective and insufficient for assessing early compositional and structural changes during the progression of post-traumatic osteoarthritis. Therefore, in this study, arthroscopic near-infrared (NIR) spectroscopy is introduced, for the first time, for in vivo evaluation of articular cartilage thickness, proteoglycan (PG) content, and collagen orientation angle. NIR spectra were acquired in vivo and in vitro from equine cartilage adjacent to experimental cartilage repair sites. As reference, digital densitometry and polarized light microscopy were used to evaluate superficial and full-thickness PG content and collagen orientation angle. To relate NIR spectra and cartilage properties, ensemble neural networks, each with two different architectures, were trained and evaluated by using Spearman's correlation analysis (ρ). The ensemble networks enabled accurate predictions for full-thickness reference properties (PG content: ρ
Identifiants
pubmed: 31062256
doi: 10.1007/s10439-019-02280-7
pii: 10.1007/s10439-019-02280-7
pmc: PMC6647474
doi:
Substances chimiques
Proteoglycans
0
Collagen
9007-34-5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1815-1826Subventions
Organisme : Kuopion Yliopistollinen Sairaala
ID : 5041750
Organisme : Kuopion Yliopistollinen Sairaala
ID : 5041744
Organisme : Academy of Finland
ID : 267551
Organisme : FP7
ID : 309962
Organisme : Dutch arthritis society
ID : LLP-12
Organisme : Dutch arthritis society
ID : LLP-22
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