Epigenome-wide DNA methylation in placentas from preterm infants: association with maternal socioeconomic status.
DNA methylation
Placenta
epigenetics
preterm children
socioeconomic adversity
Journal
Epigenetics
ISSN: 1559-2308
Titre abrégé: Epigenetics
Pays: United States
ID NLM: 101265293
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
pubmed:
8
5
2019
medline:
27
5
2020
entrez:
8
5
2019
Statut:
ppublish
Résumé
This study evaluated the hypothesis that prenatal maternal socioeconomic status (SES) adversity is associated with DNA methylation in the placenta. SES adversity was defined by the presence of, as well as a summative count of, four factors: less than college education, single marital status, food and nutritional service assistance, and public health insurance. Epigenome-wide DNA methylation was assessed using the Illumina EPIC array in 426 placentas from a sample of infants born < 28 weeks of gestation from the Extremely Low Gestational Age Newborn cohort. Associations between SES adversity and DNA methylation were assessed with robust linear regressions adjusted for covariates and controlled the false discovery rate at < 10%. We also examined whether such associations were sex specific. Indicators of SES adversity were associated with differential methylation at 33 CpG sites. Of the 33 identified CpG sites, 19 (57.6%) displayed increased methylation, and 14 (42.4%) displayed decreased methylation in association with at least one of the SES adversity factors. Sex differences were observed in DNA methylation associated with summative SES score; in which placentas derived from female pregnancies showed more robust differential CpG methylation than placentas from male pregnancies. Maternal SES adversity was associated with differential methylation of genes with key role in gene transcription and placental function, potentially altering immunity and stress response. Further investigation is needed to evaluate the role of epigenetic differences in mediating the association between maternal socioeconomic status during pregnancy and later life health outcomes in children.
Identifiants
pubmed: 31062658
doi: 10.1080/15592294.2019.1614743
pmc: PMC6615526
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
751-765Subventions
Organisme : NIEHS NIH HHS
ID : P30 ES010126
Pays : United States
Organisme : NIH HHS
ID : UH3 OD023348
Pays : United States
Organisme : NINDS NIH HHS
ID : U01 NS040069
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD092374
Pays : United States
Organisme : NIH HHS
ID : UG3 OD023348
Pays : United States
Organisme : NINR NIH HHS
ID : K23 NR017898
Pays : United States
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