Combination Therapy for Alzheimer's Disease: Perspectives of the EU/US CTAD Task Force.

Combination therapy is expected to play an important role for the treatment of Alzheimer's disease (AD). In October 2018, the European Union-North American Clinical Trials in Alzheimer's Disease Task Force (EU/US CTAD Task Force) met to discuss scientific, regulatory, and logistical challenges to the development of combination therapy for AD and current efforts to address these challenges. Task Force members unanimously agreed that successful treatment of AD will likely require combination therapy approaches that target multiple mechanisms and pathways. They further agreed on the need for global collaboration and sharing of data and resources to accelerate development of such approaches.

Déclaration de conflit d'intérêts

The Task Force was partially funded by registration fees from industrial participants. These corporations placed no restrictions on this work. Dr. Gauthier reports personal fees from TauRx, Lundbeck Institute, and Esai; and grants from Lilly and Roche, outside the submitted work. Dr. Alam reports personal fees (employment) from EIP Pharma, Inc, outside the submitted work. Dr. Fillit discloses the following consulting relationships during the past 3 years: Axovant, vTv, Lundbeck, Otsuka, Lilly, RTI, Roche, Genentech, Merck, Samus, Pfizer. He reports no conflicts of interest related to these disclosures that are relevant to this publication. Dr. Iwatsubo has nothing to disclose. Dr. Liu-Seifert reports other from Lilly, outside the submitted work. Dr. Sabbagh has consulted for Allergan, Biogen, Bracket, Neurotrope, Cortexyme, Roche, Grifols, Sanofi, VTV therapeutic, and Alzheon. Dr Sslloway has nothing to disclose; Dr. Sims, employee of Eli Lilly and Company and holder of stock in Eli Lilly and Company. Dr. Sperling is an employee of H. Lundbeck A/S, outside the submitted work. Dr. Sperling reports grants from Janssen, during the conduct of the study; personal fees from AC Immune, personal fees from Biogen, personal fees from Roche, personal fees from Eisai, personal fees from Insightec, personal fees from Takeda, personal fees from Merck, personal fees from General Electric, outside the submitted work. Dr. Welsh-Bohmer has contracts with Takeda Pharmaceutical Company and with VeraSci where she is the VP for Neurodegenerative Disorders. Dr. Touchon has nothing to disclose; Dr. Vellas reports grants from Lilly, Merck, Roche, Lundbeck, Biogen, grants from Alzheimer’s Association, European Commission, personal fees from Lilly, Merck, Roche, Biogen, outside the submitted work; Dr. Aisen reports grants from Lilly, personal fees from Proclara, other from Lilly, other from Janssen, other from Eisai, grants from Janssen, grants from NIA, grants from FNIH, grants from Alzheimer’s Association, personal fees from Merck, personal fees from Roche, personal fees from Lundbeck, personal fees from Biogen, personal fees from ImmunoBrain Checkpoint, outside the submitted work.