A longitudinal characterization of perfusion in the aging brain and associations with cognition and neural structure.
arterial spin labeling
cerebral blood flow
diffusion tensor imaging
executive functions
neuroimaging
older adults; thalamus; dorsolateral prefrontal cortex
processing speed
Journal
Human brain mapping
ISSN: 1097-0193
Titre abrégé: Hum Brain Mapp
Pays: United States
ID NLM: 9419065
Informations de publication
Date de publication:
15 08 2019
15 08 2019
Historique:
received:
05
02
2019
revised:
05
04
2019
accepted:
23
04
2019
pubmed:
8
5
2019
medline:
3
4
2020
entrez:
8
5
2019
Statut:
ppublish
Résumé
Cerebral perfusion declines across the lifespan and is altered in the early stages of several age-related neuropathologies. Little is known, however, about the longitudinal evolution of perfusion in healthy older adults, particularly when perfusion is quantified using magnetic resonance imaging with arterial spin labeling (ASL). The objective was to characterize longitudinal perfusion in typically aging adults and elucidate associations with cognition and brain structure. Adults who were functionally intact at baseline (n = 161, ages 47-89) underwent ASL imaging to quantify whole-brain gray matter perfusion; a subset (n = 136) had repeated imaging (average follow-up: 2.3 years). Neuropsychological testing at each visit was summarized into executive function, memory, and processing speed composites. Global gray matter volume, white matter microstructure (mean diffusivity), and white matter hyperintensities were also quantified. We assessed baseline associations among perfusion, cognition, and brain structure using linear regression, and longitudinal relationships using linear mixed effects models. Greater baseline perfusion, particularly in the left dorsolateral prefrontal cortex and right thalamus, was associated with better executive functions. Greater whole-brain perfusion loss was associated with worsening brain structure and declining processing speed. This study helps validate noninvasive MRI-based perfusion imaging and underscores the importance of cerebral blood flow in cognitive aging.
Identifiants
pubmed: 31062904
doi: 10.1002/hbm.24613
pmc: PMC6693488
mid: NIHMS1028795
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3522-3533Subventions
Organisme : Larry L. Hillblom Foundation
ID : 2018-A-025-FEL
Pays : International
Organisme : NIA NIH HHS
ID : K24 AG045333
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG048234
Pays : United States
Organisme : NIA NIH HHS
ID : R01AG048234
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG032289
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG023481
Pays : United States
Organisme : NIA NIH HHS
ID : K23 AG058752
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG032289
Pays : United States
Organisme : NIA NIH HHS
ID : R01AG032289
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG023501
Pays : United States
Organisme : Larry L. Hillblom Foundation
ID : 2014-A-004-NET
Pays : International
Organisme : NIA NIH HHS
ID : K23AG058752
Pays : United States
Informations de copyright
© 2019 Wiley Periodicals, Inc.
Références
J Alzheimers Dis. 2017;57(2):353-371
pubmed: 28211814
Neuroimage. 2012 Nov 15;63(3):1134-42
pubmed: 22846656
J Neurol Sci. 2000 Dec 1;181(1-2):19-28
pubmed: 11099707
Neuroimage. 2015 Jan 1;104:366-72
pubmed: 25255942
Nat Rev Neurosci. 2016 Dec;17(12):777-792
pubmed: 27829687
Ann Clin Transl Neurol. 2016 Aug 30;3(10):740-751
pubmed: 27752510
Alzheimer Dis Assoc Disord. 2010 Jan-Mar;24(1):19-27
pubmed: 20220321
Neuroimage. 2002 Mar;15(3):488-500
pubmed: 11848692
J Cereb Blood Flow Metab. 1983 Mar;3(1):62-6
pubmed: 6822619
Cereb Cortex. 2011 Jun;21(6):1426-34
pubmed: 21051551
Hum Brain Mapp. 2019 Aug 15;40(12):3522-3533
pubmed: 31062904
J Alzheimers Dis. 2013;33(4):929-39
pubmed: 23047371
PLoS One. 2012;7(11):e50425
pubmed: 23185621
Cardiovasc Psychiatry Neurol. 2012;2012:367516
pubmed: 23243502
Neuroimage. 2005 Dec;28(4):1014-21
pubmed: 16129627
Brain Behav. 2013 Nov;3(6):626-36
pubmed: 24363966
Neuroinformatics. 2011 Dec;9(4):381-400
pubmed: 21373993
Neuroimage Clin. 2017 Sep 14;16:595-603
pubmed: 28975068
J Neurosci. 2018 Mar 14;38(11):2809-2817
pubmed: 29440553
Nat Rev Neurosci. 2017 Jul;18(7):419-434
pubmed: 28515434
Neuroimage. 2011 Apr 1;55(3):954-67
pubmed: 21216294
IEEE Trans Med Imaging. 1998 Feb;17(1):87-97
pubmed: 9617910
Nat Commun. 2016 Jun 21;7:11934
pubmed: 27327500
Neuroimage Clin. 2017 Dec 06;17:751-760
pubmed: 29527482
Brain Res Cogn Brain Res. 2001 Jun;11(3):377-85
pubmed: 11339987
Alzheimers Dement. 2011 May;7(3):270-9
pubmed: 21514249
Neurobiol Aging. 2006 Jan;27(1):24-31
pubmed: 16298237
Neuroimage Clin. 2018 Jun 19;19:939-947
pubmed: 30003031
Neuroimage. 2014 May 15;92:381-97
pubmed: 24530839
Radiology. 2005 Mar;234(3):851-9
pubmed: 15734937
Neuroimage. 2011 Mar 15;55(2):468-78
pubmed: 21167947
Neuroimage. 2005 Jun;26(2):471-9
pubmed: 15907304
AJR Am J Roentgenol. 1987 Aug;149(2):351-6
pubmed: 3496763
Med Image Anal. 2006 Oct;10(5):764-85
pubmed: 16899392
Front Neurosci. 2018 Feb 06;12:33
pubmed: 29467603
J Alzheimers Dis. 2017;59(2):603-614
pubmed: 28671117
JAMA Neurol. 2015 Sep;72(9):1021-8
pubmed: 26167811
Neurology. 2006 Oct 10;67(7):1215-20
pubmed: 17030755
Neurobiol Aging. 2000 Mar-Apr;21(2):331-42
pubmed: 10867218
Eur Radiol. 2017 Mar;27(3):1169-1175
pubmed: 27334014
Science. 1988 Jul 22;241(4864):462-4
pubmed: 3260686
Nat Rev Neurosci. 2011 Nov 03;12(12):723-38
pubmed: 22048062
Magn Reson Med. 2008 Dec;60(6):1488-97
pubmed: 19025913
Biometrics. 1998 Jun;54(2):638-45
pubmed: 9629647
Nat Neurosci. 2016 Apr;19(4):533-41
pubmed: 27021938
Neurology. 2011 Nov 29;77(22):1977-85
pubmed: 22094481
Neuroimage. 1995 Jun;2(2):89-101
pubmed: 9343592
J Cereb Blood Flow Metab. 1992 Jul;12(4):571-83
pubmed: 1618936
Neuroimage. 2012 Aug 15;62(2):782-90
pubmed: 21979382
Neurology. 2013 Mar 12;80(11):1048-56
pubmed: 23390179
Diabetes Care. 2011 Feb;34(2):459-63
pubmed: 21216862
Front Neuroinform. 2014 Feb 21;8:8
pubmed: 24600385
Curr Neurovasc Res. 2012 Nov;9(4):302-9
pubmed: 22873722
Cogn Behav Neurol. 2003 Dec;16(4):211-8
pubmed: 14665820
Magn Reson Med. 1999 Jun;41(6):1246-54
pubmed: 10371458
Neuroimage. 2006 Jul 1;31(3):968-80
pubmed: 16530430
Neuroimage Clin. 2013 Apr 30;2:630-6
pubmed: 24179814
J Alzheimers Dis. 2012;31 Suppl 3:S59-74
pubmed: 22531427
Alzheimer Dis Assoc Disord. 2018 Jan-Mar;32(1):10-17
pubmed: 29240561
Trends Neurosci. 2000 Oct;23(10):475-83
pubmed: 11006464
Magn Reson Med. 2000 Sep;44(3):450-6
pubmed: 10975898
Biol Psychiatry. 2018 Apr 15;83(8):648-656
pubmed: 29275841
J Cereb Blood Flow Metab. 2013 Dec;33(12):1909-14
pubmed: 23963370
Neurology. 2006 Jun 27;66(12):1817-23
pubmed: 16801643
Ann Neurol. 1997 Jul;42(1):85-94
pubmed: 9225689
IEEE Trans Med Imaging. 2017 Aug;36(8):1758-1768
pubmed: 28422655
Front Aging Neurosci. 2014 Jul 07;6:159
pubmed: 25071567
Med Image Anal. 2008 Feb;12(1):26-41
pubmed: 17659998
Hum Brain Mapp. 2018 Dec;39(12):4663-4677
pubmed: 30004604
Neurosci Biobehav Rev. 2017 Jan;72:168-175
pubmed: 27908711
Magn Reson Med. 2004 Apr;51(4):736-43
pubmed: 15065246
Front Aging Neurosci. 2015 Jul 08;7:131
pubmed: 26217223
Neuron. 2013 Nov 20;80(4):844-66
pubmed: 24267647
J Nucl Med. 1982 May;23(5):391-9
pubmed: 6978932
Brain. 2019 Feb 1;142(2):443-459
pubmed: 30698757
Circulation. 2017 Aug 22;136(8):719-728
pubmed: 28588075
Radiology. 2015 Feb;274(2):490-9
pubmed: 25291458
Neuroimage. 2004 May;22(1):443-6
pubmed: 15110037
Arch Gen Psychiatry. 2009 Aug;66(8):811-22
pubmed: 19652121
Neuroimage. 2005 Jul 1;26(3):839-51
pubmed: 15955494
Magn Reson Med. 2003 May;49(5):796-802
pubmed: 12704760
J Magn Reson Imaging. 2018 Aug;48(2):449-458
pubmed: 29292540
Hum Brain Mapp. 2009 Sep;30(9):2927-35
pubmed: 19172645
Trends Cogn Sci. 2017 May;21(5):385-401
pubmed: 28372878
Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):284-9
pubmed: 14688411
Alzheimers Dement. 2011 May;7(3):263-9
pubmed: 21514250
Magn Reson Med. 2007 Nov;58(5):1020-7
pubmed: 17969096
Neuroimage. 2006 Apr 15;30(3):768-79
pubmed: 16412666
Magn Reson Med. 1998 Sep;40(3):383-96
pubmed: 9727941
J Cereb Blood Flow Metab. 2012 Aug;32(8):1589-99
pubmed: 22549621