Structural analysis of a replication protein encoded by a plasmid isolated from a multiple sclerosis patient.
X-ray crystal structure
bovine meat and milk factors
episomal circular DNA
multiple sclerosis
trans-acting replication initiator protein
Journal
Acta crystallographica. Section D, Structural biology
ISSN: 2059-7983
Titre abrégé: Acta Crystallogr D Struct Biol
Pays: United States
ID NLM: 101676043
Informations de publication
Date de publication:
01 May 2019
01 May 2019
Historique:
received:
15
01
2019
accepted:
23
03
2019
entrez:
8
5
2019
pubmed:
8
5
2019
medline:
10
9
2019
Statut:
ppublish
Résumé
Bovine meat and milk factors (BMMFs) are circular, single-stranded episomal DNAs that have been detected in bovine meat and milk products. BMMFs are thought to have roles in human malignant and degenerative diseases. BMMFs encode a replication initiator protein (Rep) that is actively transcribed and translated in human cells. In this study, a Rep WH1 domain encoded on a BMMF (MSBI1.176) isolated from a multiple sclerosis human brain sample was determined to 1.53 Å resolution using X-ray crystallography. The overall structure of the MSBI1.176 WH1 domain was remarkably similar to other Rep structures, despite having a low (28%) amino-acid sequence identity. The MSBI1.176 WH1 domain contained elements common to other Reps, including five α-helices, five β-strands and a hydrophobic pocket. These new findings suggest that the MSBI1.176 Rep might have comparable roles and functions to other known Reps of different origins.
Identifiants
pubmed: 31063152
pii: S2059798319003991
doi: 10.1107/S2059798319003991
pmc: PMC6503762
doi:
Substances chimiques
Trans-Activators
0
replication initiator protein
0
DNA Helicases
EC 3.6.4.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
498-504Informations de copyright
open access.
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