Exosome-Mediated Metastasis: Communication from a Distance.
bone-marrow-derived cell
cancer
exosome
extracellular matrix
extracellular vesicle
immune cell
integrins
intercellular communication
metastasis
microvesicle
pre-metastatic niche
vascular leakiness
Journal
Developmental cell
ISSN: 1878-1551
Titre abrégé: Dev Cell
Pays: United States
ID NLM: 101120028
Informations de publication
Date de publication:
06 05 2019
06 05 2019
Historique:
received:
11
03
2019
revised:
02
04
2019
accepted:
08
04
2019
entrez:
8
5
2019
pubmed:
8
5
2019
medline:
7
1
2020
Statut:
ppublish
Résumé
Metastasis, a critical phase of tumor progression, remains a primary challenge in treating cancer and a major cause of cancer mortality. Cell-cell communication via extracellular vesicles (exosomes and microvesicles) between primary tumor cells and the microenvironment of distant organs is crucial for pre-metastatic niche (PMN) formation and metastasis. Here, we review work on the contribution of exosome cargo to cancer progression, the role of exosomes in PMN establishment, and the function of exosomes in organotropic metastasis. We also describe the clinical utility of exosomes.
Identifiants
pubmed: 31063754
pii: S1534-5807(19)30281-3
doi: 10.1016/j.devcel.2019.04.011
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
347-360Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.