Regenerative Repair of Volumetric Muscle Loss Injury is Sensitive to Age.
VML
animal model
musculoskeletal
orthopedics
tibialis anterior
Journal
Tissue engineering. Part A
ISSN: 1937-335X
Titre abrégé: Tissue Eng Part A
Pays: United States
ID NLM: 101466659
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
pubmed:
9
5
2019
medline:
29
5
2021
entrez:
9
5
2019
Statut:
ppublish
Résumé
In this study, the influence of age on effectiveness of regenerative repair for the treatment of volumetric muscle loss (VML) injury was explored. Tibialis anterior (TA) VML injuries were repaired in both 3- and 18-month-old animal models (Fischer 344 rat) using allogeneic decellularized skeletal muscle (DSM) scaffolds supplemented with autologous minced muscle (MM) paste. Within the 3-month animal group, TA peak contractile force was significantly improved (79% of normal) in response to DSM+MM repair. However, within the 18-month animal group, muscle force following repair (57% of normal) was not significantly different from unrepaired VML controls (59% of normal). Within the 3-month animal group, repair with DSM+MM generally reduced scarring at the site of VML repair, whereas scarring and a loss of contractile tissue was notable at the site of repair within the 18-month group. Within 3-month animals, expression of myogenic genes (
Identifiants
pubmed: 31064280
doi: 10.1089/ten.TEA.2019.0034
pmc: PMC6983754
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3-14Références
Curr Top Dev Biol. 2011;96:85-119
pubmed: 21621068
Biotechnol Prog. 2016 May;32(3):745-55
pubmed: 26949076
Biores Open Access. 2015 Mar 01;4(1):198-208
pubmed: 26309796
Nat Commun. 2017 Jun 20;8:15613
pubmed: 28631758
NPJ Regen Med. 2018 Sep 17;3:16
pubmed: 30245849
FEBS J. 2013 Sep;280(17):4131-48
pubmed: 23663276
Nat Rev Immunol. 2017 Mar;17(3):165-178
pubmed: 28163303
J Trauma. 2008 Feb;64(2):295-9
pubmed: 18301189
Nat Cell Biol. 2010 Feb;12(2):153-63
pubmed: 20081841
Cell Cycle. 2005 Mar;4(3):407-10
pubmed: 15725724
Res Exp Med (Berl). 1985;185(2):95-106
pubmed: 3992061
PLoS One. 2017 Oct 17;12(10):e0186593
pubmed: 29040321
Biomaterials. 2010 Oct;31(29):7475-84
pubmed: 20638716
Eur J Appl Physiol. 2017 Jul;117(7):1463-1472
pubmed: 28493029
Tissue Eng Part A. 2010 Sep;16(9):2871-81
pubmed: 20412030
Tissue Eng Part A. 2016 Oct;22(19-20):1129-1139
pubmed: 27562630
Tissue Eng Part A. 2014 Feb;20(3-4):705-15
pubmed: 24066899
Tissue Eng Part A. 2016 Oct;22(19-20):1151-1163
pubmed: 27570911
Cell Tissue Res. 2014 Dec;358(3):857-73
pubmed: 25300647
Orthopedics. 2010 Jul 13;33(7):511
pubmed: 20608620
J Gerontol A Biol Sci Med Sci. 1995 Nov;50 Spec No:96-100
pubmed: 7493227
Exp Gerontol. 2016 Oct;83:37-46
pubmed: 27435497
Muscle Nerve. 1998 Jun;21(6):819-22
pubmed: 9585342
Cell Transplant. 2018 Oct 9;:963689718805370
pubmed: 30298751
Sci Rep. 2018 May 30;8(1):8398
pubmed: 29849047
J Morphol. 1968 Aug;125(4):447-72
pubmed: 5687378
Physiol Rep. 2017 Apr;5(7):
pubmed: 28400501
NPJ Regen Med. 2016 Jul 21;1:16008
pubmed: 29302336
Am J Physiol Regul Integr Comp Physiol. 2003 May;284(5):R1249-54
pubmed: 12676746
Science. 2007 Aug 10;317(5839):807-10
pubmed: 17690295
J Cell Sci. 2007 Feb 15;120(Pt 4):692-701
pubmed: 17264149
Skelet Muscle. 2011 May 04;1(1):21
pubmed: 21798099
Stem Cell Res Ther. 2018 Apr 3;9(1):88
pubmed: 29615126
Tissue Eng Part A. 2012 Jun;18(11-12):1213-28
pubmed: 22439962
Ageing Res Rev. 2016 Mar;26:22-36
pubmed: 26690801
Physiol Rep. 2013 Sep;1(4):e00075
pubmed: 24303150
Tissue Eng Part A. 2012 Oct;18(19-20):1941-8
pubmed: 22906411
J Trauma. 2011 Jul;71(1 Suppl):S120-4
pubmed: 21795870
Am J Physiol Cell Physiol. 2007 May;292(5):C1660-71
pubmed: 17151142
Ann N Y Acad Sci. 1998 Nov 20;854:78-91
pubmed: 9928422
Am J Physiol Regul Integr Comp Physiol. 2005 Feb;288(2):R345-53
pubmed: 15637171
J Biomech. 2014 Jun 27;47(9):2013-21
pubmed: 24280565
Plast Reconstr Surg. 2007 Jun;119(7):2118-26
pubmed: 17519710
Transplantation. 2001 Jun 15;71(11):1631-40
pubmed: 11435976
J Intern Med. 2011 Mar;269(3):243-57
pubmed: 21205023
Biomaterials. 2018 May;164:70-79
pubmed: 29499437
Hum Mol Genet. 2002 Feb 1;11(3):263-72
pubmed: 11823445
Am J Physiol Cell Physiol. 2013 Oct 1;305(7):C761-75
pubmed: 23885064
Med Sci Sports Exerc. 1995 Jul;27(7):1022-32
pubmed: 7564969
J Biol Chem. 2013 Jan 18;288(3):1489-99
pubmed: 23184935
J Anat. 1984 Dec;139 ( Pt 4):677-89
pubmed: 6526719
Compr Physiol. 2011 Oct;1(4):2029-62
pubmed: 23733696
Nature. 2005 Feb 17;433(7027):760-4
pubmed: 15716955
J Surg Res. 2012 Aug;176(2):490-502
pubmed: 22341350
J Invest Dermatol. 1993 Dec;101(6):875-9
pubmed: 8245516
Biomaterials. 2013 Apr;34(13):3324-35
pubmed: 23384793
Ann N Y Acad Sci. 1964 Nov 30;120:789-801
pubmed: 14235292
PLoS One. 2018 Jan 12;13(1):e0191245
pubmed: 29329332
PLoS One. 2013 Aug 15;8(8):e72121
pubmed: 23977226
Curr Top Dev Biol. 2011;96:167-201
pubmed: 21621071