Chronic kidney disease and HIV in the era of antiretroviral treatment: findings from a 10-year cohort study in a west African setting.
Adult
Age Factors
Anti-HIV Agents
/ adverse effects
Burkina Faso
/ epidemiology
Cohort Studies
Creatinine
/ blood
Didanosine
/ adverse effects
Dideoxynucleosides
/ adverse effects
Female
Follow-Up Studies
Glomerular Filtration Rate
/ drug effects
HIV Infections
/ complications
Humans
Hypertension
/ complications
Incidence
Linear Models
Male
Middle Aged
Prevalence
Renal Insufficiency, Chronic
/ diagnosis
Risk Factors
Stavudine
/ adverse effects
Tenofovir
/ adverse effects
Time Factors
Zidovudine
/ adverse effects
Africa
Antiretroviral treatment
Burkina Faso
CKD
Epidemiology
HIV
Journal
BMC nephrology
ISSN: 1471-2369
Titre abrégé: BMC Nephrol
Pays: England
ID NLM: 100967793
Informations de publication
Date de publication:
07 05 2019
07 05 2019
Historique:
received:
22
10
2018
accepted:
15
04
2019
entrez:
9
5
2019
pubmed:
9
5
2019
medline:
6
6
2020
Statut:
epublish
Résumé
It has been reported that people living with HIV in West Africa exhibited the highest risks for chronic kidney disease (CKD) in the world. Here, we aimed at determining the CKD frequency and changes in kidney function during antiretroviral treatment (ART) in a large cohort of HIV-patients followed in Burkina Faso. We included ART-naive adults who initiated ART at the Day Care Unit of the Souro Sanou University Hospital between 01/01/2007 and 12/31/2016. We assessed the estimated glomerular filtration rate (eGFR) by serum creatinine using the Modification of Diet in Renal Disease (MDRD) equation. Following the K/DOQI recommendations, CKD was defined as eGFR < 60 ml/min/1.73m Three thousand, one hundred and thirty-eight patients (72% women) were followed for a median (IQR) of 4.5(2.2-6.9) years. At baseline, median eGFR (IQR) was 110.7(94.4-128.4) ml/min/1.73m Our findings do not confirm the high risk of CKD reported in previous studies of West Africans with HIV, but support the recommendations for early initiation of ART and close kidney function monitoring in patients with HBP or aged ≥40 yr.
Sections du résumé
BACKGROUND
It has been reported that people living with HIV in West Africa exhibited the highest risks for chronic kidney disease (CKD) in the world. Here, we aimed at determining the CKD frequency and changes in kidney function during antiretroviral treatment (ART) in a large cohort of HIV-patients followed in Burkina Faso.
METHODS
We included ART-naive adults who initiated ART at the Day Care Unit of the Souro Sanou University Hospital between 01/01/2007 and 12/31/2016. We assessed the estimated glomerular filtration rate (eGFR) by serum creatinine using the Modification of Diet in Renal Disease (MDRD) equation. Following the K/DOQI recommendations, CKD was defined as eGFR < 60 ml/min/1.73m
RESULTS
Three thousand, one hundred and thirty-eight patients (72% women) were followed for a median (IQR) of 4.5(2.2-6.9) years. At baseline, median eGFR (IQR) was 110.7(94.4-128.4) ml/min/1.73m
CONCLUSIONS
Our findings do not confirm the high risk of CKD reported in previous studies of West Africans with HIV, but support the recommendations for early initiation of ART and close kidney function monitoring in patients with HBP or aged ≥40 yr.
Identifiants
pubmed: 31064340
doi: 10.1186/s12882-019-1335-9
pii: 10.1186/s12882-019-1335-9
pmc: PMC6505177
doi:
Substances chimiques
Anti-HIV Agents
0
Dideoxynucleosides
0
Zidovudine
4B9XT59T7S
Tenofovir
99YXE507IL
Creatinine
AYI8EX34EU
Stavudine
BO9LE4QFZF
Didanosine
K3GDH6OH08
abacavir
WR2TIP26VS
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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