Circular RNAS: novel biomarkers of disease activity in systemic lupus erythematosus?
circular RNAs
epigenetics
lupus
pathophysiology
Journal
Clinical science (London, England : 1979)
ISSN: 1470-8736
Titre abrégé: Clin Sci (Lond)
Pays: England
ID NLM: 7905731
Informations de publication
Date de publication:
15 May 2019
15 May 2019
Historique:
received:
13
11
2018
revised:
13
04
2019
accepted:
23
04
2019
entrez:
9
5
2019
pubmed:
9
5
2019
medline:
4
7
2019
Statut:
epublish
Résumé
Circular RNAs (circRNAs) are a class of non-coding RNAs that regulate gene expression by acting as competitive endogenous RNAs (ceRNAs) and modulating gene transcription. Several studies support the implication of circRNAs in a variety of human diseases, but research on the role of circRNAs in systemic lupus erythematosus (SLE) is lacking. In a study recently published in Clinical Science (2018), Zhang et al. identified hsa_circ_0012919 as a potential biomarker of disease activity in SLE patients. The authors observed different circRNA expression between SLE patients and healthy controls, an association with clinical variables and with the abnormal DNA methylation present in SLE CD4
Identifiants
pubmed: 31064795
pii: CS20180826
doi: 10.1042/CS20180826
doi:
Substances chimiques
Biomarkers
0
CD27 Ligand
0
CD70 protein, human
0
MicroRNAs
0
Types de publication
Journal Article
Comment
Langues
eng
Sous-ensembles de citation
IM
Pagination
1049-1052Commentaires et corrections
Type : CommentOn
Informations de copyright
© 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.