Diagnostic accuracy of faecal calprotectin in patients with active perianal fistulas.
Adolescent
Adult
Aged
Anal Canal
/ immunology
Anus Diseases
/ diagnosis
Biomarkers
/ analysis
Crohn Disease
/ complications
Diagnosis, Differential
Feces
/ chemistry
Female
Humans
Intestinal Mucosa
/ immunology
Leukocyte L1 Antigen Complex
/ analysis
Male
Middle Aged
Prospective Studies
ROC Curve
Rectal Fistula
/ diagnosis
Retrospective Studies
Young Adult
Crohn's disease
Faecal calprotectin
biomarker
diagnostic accuracy
perianal fistula
Journal
United European gastroenterology journal
ISSN: 2050-6406
Titre abrégé: United European Gastroenterol J
Pays: England
ID NLM: 101606807
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
10
09
2018
accepted:
03
02
2019
entrez:
9
5
2019
pubmed:
9
5
2019
medline:
9
5
2019
Statut:
ppublish
Résumé
Faecal calprotectin (FC) is a marker of mucosal inflammation. The aim of this study was to determine the diagnostic accuracy of FC to (a) differentiate between perianal fistulizing Crohn's disease (pCD) and cryptoglandular perianal fistulas; and (b) detect mucosal inflammation in pCD. Patients with active perianal fistulas who had FC measured and a complete ileocolonoscopy within 10 weeks were retrospectively included. Fifty-six patients were included (pCD, FC discriminates pCD from cryptoglandular fistulas, even in the absence of intestinal ulcers. In active pCD, an elevated FC does not accurately predict the presence of ulcers and should be interpreted with caution.
Sections du résumé
Background
Faecal calprotectin (FC) is a marker of mucosal inflammation.
Objective
The aim of this study was to determine the diagnostic accuracy of FC to (a) differentiate between perianal fistulizing Crohn's disease (pCD) and cryptoglandular perianal fistulas; and (b) detect mucosal inflammation in pCD.
Methods
Patients with active perianal fistulas who had FC measured and a complete ileocolonoscopy within 10 weeks were retrospectively included.
Results
Fifty-six patients were included (pCD,
Conclusion
FC discriminates pCD from cryptoglandular fistulas, even in the absence of intestinal ulcers. In active pCD, an elevated FC does not accurately predict the presence of ulcers and should be interpreted with caution.
Identifiants
pubmed: 31065367
doi: 10.1177/2050640619834464
pii: 10.1177_2050640619834464
pmc: PMC6488796
doi:
Substances chimiques
Biomarkers
0
Leukocyte L1 Antigen Complex
0
Types de publication
Journal Article
Observational Study
Langues
eng
Pagination
496-506Références
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