The Multiple Sclerosis Functional Composite and Symbol Digit Modalities Test as outcome measures in pediatric multiple sclerosis.
MSFC
Multiple sclerosis
SDMT
outcome measure
pediatric
Journal
Multiple sclerosis journal - experimental, translational and clinical
ISSN: 2055-2173
Titre abrégé: Mult Scler J Exp Transl Clin
Pays: United States
ID NLM: 101668877
Informations de publication
Date de publication:
Historique:
received:
08
02
2019
accepted:
03
04
2019
entrez:
9
5
2019
pubmed:
9
5
2019
medline:
9
5
2019
Statut:
epublish
Résumé
There is an increasing number of pediatric multiple sclerosis (MS) clinical trials occurring; however, data validating outcome metrics that accurately capture functional disability within pediatric cohorts are limited. The aim of this study was to investigate the ability of the MS Functional Composite (MSFC) and Symbol Digit Modalities Test (SDMT) to distinguish functional disability in pediatric MS patients. A total of 20 pediatric MS patients and 40 age and sex-matched controls completed the SDMT and MSFC components: a timed 25-foot walk (T25FW); 9-hole peg test (9HPT); and paced auditory serial addition test (PASAT). Pediatric MS patients exhibited low levels of disability on EDSS, median [range]: 1.5 [1.0-3.0]. Compared with controls, MS patients performed significantly lower on SDMT ( Despite low levels of neurologic disability as measured by EDSS, pediatric patients with MS exhibit impaired performance in leg function, upper limb fine motor function, and auditory/visuospatial processing speeds, supporting the value of the MSFC and SDMT in this population. Longitudinal studies are needed to further validate their utility.
Sections du résumé
BACKGROUND
BACKGROUND
There is an increasing number of pediatric multiple sclerosis (MS) clinical trials occurring; however, data validating outcome metrics that accurately capture functional disability within pediatric cohorts are limited.
OBJECTIVE
OBJECTIVE
The aim of this study was to investigate the ability of the MS Functional Composite (MSFC) and Symbol Digit Modalities Test (SDMT) to distinguish functional disability in pediatric MS patients.
METHODS
METHODS
A total of 20 pediatric MS patients and 40 age and sex-matched controls completed the SDMT and MSFC components: a timed 25-foot walk (T25FW); 9-hole peg test (9HPT); and paced auditory serial addition test (PASAT).
RESULTS
RESULTS
Pediatric MS patients exhibited low levels of disability on EDSS, median [range]: 1.5 [1.0-3.0]. Compared with controls, MS patients performed significantly lower on SDMT (
CONCLUSIONS
CONCLUSIONS
Despite low levels of neurologic disability as measured by EDSS, pediatric patients with MS exhibit impaired performance in leg function, upper limb fine motor function, and auditory/visuospatial processing speeds, supporting the value of the MSFC and SDMT in this population. Longitudinal studies are needed to further validate their utility.
Identifiants
pubmed: 31065380
doi: 10.1177/2055217319846141
pii: 10.1177_2055217319846141
pmc: PMC6488791
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2055217319846141Références
J Pediatr. 2001 Sep;139(3):443-6
pubmed: 11562627
Neuropediatrics. 2003 Jun;34(3):120-6
pubmed: 12910434
Neurology. 2003 Dec 9;61(11):1528-32
pubmed: 14663037
Neurology. 2005 Mar 8;64(5):891-4
pubmed: 15753431
Neurol Sci. 2005 Dec;26 Suppl 4:S183-6
pubmed: 16388355
Neurology. 2006 Aug 8;67(3):511-3
pubmed: 16775230
N Engl J Med. 2007 Jun 21;356(25):2603-13
pubmed: 17582070
J Neurol. 2008 Feb;255(2):280-7
pubmed: 18204919
Annu Rev Neurosci. 2008;31:247-69
pubmed: 18558855
Arch Neurol. 2009 Jan;66(1):54-9
pubmed: 19139299
Neurology. 2009 Feb 17;72(7):602-8
pubmed: 19221292
Neurology. 2010 Sep 28;75(13):1134-40
pubmed: 20876467
Ann Neurol. 2011 Feb;69(2):292-302
pubmed: 21387374
JAMA Neurol. 2013 Apr;70(4):469-75
pubmed: 23420110
Mult Scler. 2013 Sep;19(10):1261-7
pubmed: 23572237
Neurology. 2013 Oct 1;81(14):1215-21
pubmed: 23966255
PLoS One. 2014 Feb 26;9(2):e85741
pubmed: 24586244
J Neurol Sci. 2014 Jun 15;341(1-2):79-84
pubmed: 24792098
Neurology. 2014 Oct 14;83(16):1432-8
pubmed: 25217060
Neurology. 2016 Aug 30;87(9 Suppl 2):S74-81
pubmed: 27572865
Mult Scler Relat Disord. 2016 Nov;10:73-78
pubmed: 27919503
Neurol Sci. 2017 Apr;38(4):635-642
pubmed: 28078569
Dev Neuropsychol. 2017;42(5):299-308
pubmed: 28872902
Neurology. 1983 Nov;33(11):1444-52
pubmed: 6685237