Orbital relapse of retinoblastoma in patients with high-risk histopathology features.
eye
orbital tumors
retinoblastoma
tumor
Journal
Therapeutic advances in ophthalmology
ISSN: 2515-8414
Titre abrégé: Ther Adv Ophthalmol
Pays: United States
ID NLM: 101728805
Informations de publication
Date de publication:
Historique:
received:
18
02
2019
accepted:
21
03
2019
entrez:
9
5
2019
pubmed:
9
5
2019
medline:
9
5
2019
Statut:
epublish
Résumé
To describe the clinical picture of orbital relapse of retinoblastoma following uncomplicated enucleation. Case series of two patients with group E retinoblastoma with high-risk features on histopathology, namely, post-laminar optic nerve extension in one patient, and massive choroidal tumor infiltration in the other. Neither of them received adjuvant chemotherapy post enucleation. Both patients had orbital relapse of tumor within 4 months from enucleation, manifesting as implant migration and unstable conformer. Systemic chemotherapy and external beam radiotherapy to the orbit resulted in complete tumor regression. Both patients were tumor free at the last follow up. Implant migration post enucleation should raise the suspicion for orbital relapse of retinoblastoma. High-risk histopathology features should increase the alert in an otherwise uncomplicated enucleation for retinoblastoma.
Identifiants
pubmed: 31065625
doi: 10.1177/2515841419844080
pii: 10.1177_2515841419844080
pmc: PMC6487749
doi:
Types de publication
Case Reports
Langues
eng
Pagination
2515841419844080Déclaration de conflit d'intérêts
Conflict of interest statement: The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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