The zinc-finger transcription factor MAZR regulates iNKT cell subset differentiation.


Journal

Cellular and molecular life sciences : CMLS
ISSN: 1420-9071
Titre abrégé: Cell Mol Life Sci
Pays: Switzerland
ID NLM: 9705402

Informations de publication

Date de publication:
Nov 2019
Historique:
received: 18 07 2018
accepted: 29 04 2019
revised: 19 04 2019
pubmed: 9 5 2019
medline: 5 11 2019
entrez: 9 5 2019
Statut: ppublish

Résumé

Invariant natural killer T (iNKT) cells represent a subgroup of innate-like T cells and play an important role in immune responses against certain pathogens. In addition, they have been linked to autoimmunity and antitumor immunity. iNKT cells consist of several subsets with distinct functions; however, the transcriptional networks controlling iNKT subset differentiation are still not fully characterized. Myc-associated zinc-finger-related factor (MAZR, also known as PATZ1) is an essential transcription factor for CD8

Identifiants

pubmed: 31065747
doi: 10.1007/s00018-019-03119-z
pii: 10.1007/s00018-019-03119-z
pmc: PMC6803753
doi:

Substances chimiques

Neoplasm Proteins 0
Repressor Proteins 0
Transcription Factors 0
Zfp278 protein, mouse 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

4391-4404

Subventions

Organisme : Austrian Science Fund FWF
ID : P 27747
Pays : Austria
Organisme : Austrian Science Fund
ID : P23669
Organisme : Austrian Science Fund
ID : W1212
Organisme : Austrian Science Fund FWF
ID : P 29790
Pays : Austria
Organisme : Austrian Science Fund
ID : SFB F4612-B28
Organisme : Austrian Science Fund
ID : MCCA W 1248-B30
Organisme : Austrian Science Fund
ID : P29790
Organisme : Austrian Science Fund
ID : P27747
Organisme : Austrian Science Fund
ID : P23641

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Auteurs

Maria Jonah Orola (MJ)

Division of Immunobiology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, 1090, Vienna, Austria.
Institute of Specific Prophylaxis and Tropical Medicine, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, 1090, Vienna, Austria.

Caroline Tizian (C)

Division of Immunobiology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, 1090, Vienna, Austria.
Institute of Microbiology and Infectious Diseases and Immunology, Charité-University Medical Centre Berlin (CBF), 12203, Berlin, Germany.

Ci Zhu (C)

Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, 1090, Vienna, Austria.

Liisa Andersen (L)

Division of Immunobiology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, 1090, Vienna, Austria.

Alexandra Franziska Gülich (AF)

Division of Immunobiology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, 1090, Vienna, Austria.

Marlis Alteneder (M)

Division of Immunobiology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, 1090, Vienna, Austria.

Tatjana Stojakovic (T)

Clinical Institute of Medical and Chemical Laboratory Diagnostics, University Hospital Graz, 8036, Graz, Austria.

Ursula Wiedermann (U)

Institute of Specific Prophylaxis and Tropical Medicine, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, 1090, Vienna, Austria.

Michael Trauner (M)

Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, 1090, Vienna, Austria.

Wilfried Ellmeier (W)

Division of Immunobiology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, 1090, Vienna, Austria.

Shinya Sakaguchi (S)

Division of Immunobiology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, 1090, Vienna, Austria. shinya.sakaguchi@meduniwien.ac.at.

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Classifications MeSH