Painful and Painless Diabetic Neuropathies: What Is the Difference?
Diabetes
Diabetic neuropathy
Neuropathic pain
Painful diabetic neuropathy
Peripheral neuropathy
Small fiber neuropathy
Journal
Current diabetes reports
ISSN: 1539-0829
Titre abrégé: Curr Diab Rep
Pays: United States
ID NLM: 101093791
Informations de publication
Date de publication:
07 05 2019
07 05 2019
Historique:
entrez:
9
5
2019
pubmed:
9
5
2019
medline:
7
2
2020
Statut:
epublish
Résumé
The prevalence of diabetes mellitus and its chronic complications are increasing to epidemic proportions. This will unfortunately result in massive increases in diabetic distal symmetrical polyneuropathy (DPN) and its troublesome sequelae, including disabling neuropathic pain (painful-DPN), which affects around 25% of patients with diabetes. Why these patients develop neuropathic pain, while others with a similar degree of neuropathy do not, is not clearly understood. This review will look at recent advances that may shed some light on the differences between painful and painless-DPN. Gender, clinical pain phenotyping, serum biomarkers, brain imaging, genetics, and skin biopsy findings have been reported to differentiate painful- from painless-DPN. Painful-DPN seems to be associated with female gender and small fiber dysfunction. Moreover, recent brain imaging studies have found neuropathic pain signatures within the central nervous system; however, whether this is the cause or effect of the pain is yet to be determined. Further research is urgently required to develop our understanding of the pathogenesis of pain in DPN in order to develop new and effective mechanistic treatments for painful-DPN.
Identifiants
pubmed: 31065863
doi: 10.1007/s11892-019-1150-5
pii: 10.1007/s11892-019-1150-5
pmc: PMC6505492
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
32Références
Pain. 2014 Feb;155(2):250-260
pubmed: 24103402
Diabetes Res Clin Pract. 2016 Jan;111:44-50
pubmed: 26548603
Diabetologia. 2001 Nov;44(11):1973-88
pubmed: 11719828
Neurology. 1993 Apr;43(4):817-24
pubmed: 8469345
J Pain Symptom Manage. 2005 Oct;30(4):374-85
pubmed: 16256902
Sci Rep. 2018 Feb 19;8(1):3283
pubmed: 29459766
Diabetes Res Clin Pract. 2018 May;139:147-154
pubmed: 29518491
Diabet Med. 2009 Mar;26(3):247-52
pubmed: 19317819
Eur J Neurol. 2010 Aug;17(8):1010-8
pubmed: 20298428
Diabetologia. 1996 Mar;39(3):329-35
pubmed: 8721779
Muscle Nerve. 2015 Apr;51(4):505-13
pubmed: 25130671
Diabetes. 2002 Dec;51(12):3545-53
pubmed: 12453912
Arch Intern Med. 2008 Apr 14;168(7):771-2
pubmed: 18413561
Diabet Med. 2018 Jul;35(7):887-894
pubmed: 29608799
PLoS One. 2018 Feb 6;13(2):e0192333
pubmed: 29408929
Diabet Med. 2019 Jan;36(1):44-51
pubmed: 30102801
Diabetes Metab Syndr. 2018 Apr - Jun;12(2):111-116
pubmed: 29042249
Diabetes Care. 2017 Apr;40(4):569-576
pubmed: 28174259
J Clin Endocrinol Metab. 2009 Jun;94(6):2157-63
pubmed: 19276232
Diabetologia. 2008 Nov;51(11):2088-92
pubmed: 18773192
Diabet Med. 2016 Nov;33(11):1466-1476
pubmed: 26822889
Curr Diab Rep. 2012 Aug;12(4):384-92
pubmed: 22570215
Diab Vasc Dis Res. 2006 Sep;3(2):108-19
pubmed: 17058631
Diabetes Care. 2014 Sep;37(9):2640-2
pubmed: 24969576
Neurology. 2007 Jul 3;69(1):42-9
pubmed: 17606879
Diabetes Res Clin Pract. 2000 Feb;47(2):123-8
pubmed: 10670912
Neuroimage. 2000 Jun;11(6 Pt 1):805-21
pubmed: 10860804
Br J Anaesth. 2008 Jul;101(1):32-9
pubmed: 18556697
Diabetes Care. 1994 Oct;17(10):1200-2
pubmed: 7821144
Pain. 2017 Apr;158(4):560-568
pubmed: 27941499
J Neurol. 2015 Jan;262(1):203-12
pubmed: 25371017
Diabetes. 1986 Feb;35(2):192-7
pubmed: 3002887
Diabetes Care. 2004 Oct;27(10):2386-91
pubmed: 15451905
J Neurol Sci. 2015 Aug 15;355(1-2):131-7
pubmed: 26071889
Hum Brain Mapp. 2013 Oct;34(10):2733-46
pubmed: 22522975
Diabetologia. 2003 May;46(5):683-8
pubmed: 12739016
Diabetologia. 2017 Dec;60(12):2495-2503
pubmed: 28914336
BMC Neurol. 2007 Aug 03;7:21
pubmed: 17683543
Ann Neurol. 2012 Jan;71(1):26-39
pubmed: 21698661
Metabolism. 2016 Apr;65(4):463-74
pubmed: 26975538
J Neurol Sci. 2018 May 15;388:103-106
pubmed: 29627001
Diabetes Care. 2013 Oct;36(10):3208-15
pubmed: 23757426
Pain. 2011 Feb;152(2):410-418
pubmed: 21185650
J Pain. 2017 Jul;18(7):757-777
pubmed: 28254585
Curr Diab Rep. 2016 Mar;16(3):29
pubmed: 26897744
J Pain Res. 2011;4:169-75
pubmed: 21811392
Rev Neurosci. 2015;26(6):609-32
pubmed: 26200810
Diabetologia. 1992 Feb;35(2):155-9
pubmed: 1547920
Pain. 2018 Mar;159(3):416-426
pubmed: 29140928
Curr Opin Anaesthesiol. 2013 Oct;26(5):588-93
pubmed: 23995063
Diabetologia. 2003 Jul;46(7):934-9
pubmed: 12819899
BMJ Open Diabetes Res Care. 2016 Feb 10;4(1):e000148
pubmed: 27026808
N Engl J Med. 2005 Jan 27;352(4):341-50
pubmed: 15673800
Diabetes Res Clin Pract. 2018 Oct;144:177-191
pubmed: 30201394
Diabetes Care. 2017 Jan;40(1):136-154
pubmed: 27999003
Diabetes Metab. 2009 Jun;35(3):206-13
pubmed: 19297223
Diabetes Care. 2003 Sep;26(9):2697-8
pubmed: 12941745
Mol Pain. 2010 May 19;6:28
pubmed: 20482876
Front Pain Res (Lausanne). 2021 Oct 22;2:731658
pubmed: 35295465
Diabetologia. 1999 Nov;42(11):1308-13
pubmed: 10550414
Eur J Pain. 2010 Aug;14(7):693-9
pubmed: 20056558
J Family Community Med. 2018 Jan-Apr;25(1):43-47
pubmed: 29386961
Eur J Neurosci. 2016 Jul;44(1):1779-86
pubmed: 27152754
Diabetes Care. 2018 May;41(5):1068-1075
pubmed: 29487078
PLoS One. 2017 Jul 18;12(7):e0180175
pubmed: 28719619
Ann Clin Transl Neurol. 2018 Feb 14;5(4):397-405
pubmed: 29687018
Eur J Pain. 2015 Mar;19(3):392-9
pubmed: 24974787
Clin J Pain. 2015 Nov;31(11):976-82
pubmed: 25585270
Skin Pharmacol Appl Skin Physiol. 2001 Jul-Aug;14(4):226-33
pubmed: 11464105
Eur J Pain. 2018 Nov;22(10):1727-1734
pubmed: 29885017
Diabetes Care. 2002 Oct;25(10):1699-703
pubmed: 12351464
Diabetes Res Clin Pract. 2015 May;108(2):201-9
pubmed: 25700626
N Engl J Med. 2007 Jul 19;357(3):266-81
pubmed: 17634462
Diabetes Res Clin Pract. 2015 Aug;109(2):215-25
pubmed: 26008721
J Neurol Neurosurg Psychiatry. 2018 Oct;89(10):1082-1087
pubmed: 29627772
J Neurol. 2008 Aug;255(8):1197-202
pubmed: 18574618
Lancet Neurol. 2017 Nov;16(11):934-944
pubmed: 29029847
Pain. 2007 Jun;129(3):256-259
pubmed: 17451879
Diabetes Care. 2014 Jun;37(6):1681-8
pubmed: 24658391
PLoS One. 2017 Aug 28;12(8):e0182081
pubmed: 28846690
Diabetes Care. 2008 Jan;31(1):140-5
pubmed: 17934147
Pain. 2017 Dec;158(12):2340-2353
pubmed: 28858986
Med Princ Pract. 2015;24(3):250-6
pubmed: 25720672
Diabetes Metab Syndr Obes. 2011;4:401-8
pubmed: 22253538
Pain. 2018 Sep;159(9):1867-1876
pubmed: 29863528
Br J Ophthalmol. 2016 Jan;100(1):9-14
pubmed: 25677672
Eur J Pain. 2011 Feb;15(2):153-60
pubmed: 20619708
Neurotherapeutics. 2009 Oct;6(4):638-47
pubmed: 19789069
J Diabetes Investig. 2018 Sep;9(5):1016-1018
pubmed: 29277966
Nat Rev Neurol. 2017 Apr;13(4):203-216
pubmed: 28303912
Pain. 2016 Feb;157 Suppl 1:S72-S80
pubmed: 26785159
Pain. 2006 Aug;123(3):231-243
pubmed: 16697110
Eur J Pain. 2006 Jan;10(1):77-88
pubmed: 16291301
J Chem Neuroanat. 2011 Jan;41(1):1-12
pubmed: 20969950
Diabet Med. 1992 May;9(4):359-65
pubmed: 1600708
Pain. 2016 May;157(5):1132-1145
pubmed: 27088890
J Neurol. 2011 Oct;258(10):1852-64
pubmed: 21472496
Pain. 2018 Dec;159(12):2658-2666
pubmed: 30161042
Diabetes Care. 2015 Jan;38(1):91-6
pubmed: 25325880
Brain Res. 2009 May 1;1268:154-161
pubmed: 19285053
Diabetes Care. 2009 Mar;32(3):451-5
pubmed: 19074993
Diabet Med. 2004 Sep;21(9):976-82
pubmed: 15317601
N Engl J Med. 2013 Apr 11;368(15):1388-97
pubmed: 23574118
J Pain. 2013 Sep;14(9):941-7
pubmed: 23685187
Br J Anaesth. 2011 Oct;107(4):490-502
pubmed: 21852280
Inflammopharmacology. 2014 Dec;22(6):327-32
pubmed: 25326758
Diabetes Care. 2010 Oct;33(10):2285-93
pubmed: 20876709
Diabetes. 2007 Aug;56(8):2148-54
pubmed: 17513704
Diabetes Care. 2011 Mar;34(3):718-20
pubmed: 21282344
Pain Med. 2009 Mar;10(2):393-400
pubmed: 19207236
J Diabetes Complications. 2015 Mar;29(2):212-7
pubmed: 25498300
Curr Diab Rep. 2018 Jan 23;18(1):1
pubmed: 29362940
BMC Neurosci. 2009 Nov 26;10:138
pubmed: 19941658
Diabetes Care. 2011 Oct;34(10):2220-4
pubmed: 21852677
Nat Med. 2012 Jun;18(6):926-33
pubmed: 22581285
Diabetes Care. 2010 Jul;33(7):1585-90
pubmed: 20587724
Diabetes Care. 2010 Dec;33(12):2654-9
pubmed: 20841612
Eur J Pharmacol. 2018 Aug 15;833:472-523
pubmed: 29966615
Clin J Pain. 2006 Mar-Apr;22(3):261-5
pubmed: 16514326
Diabetes Care. 1993 May;16(5):722-7
pubmed: 8495611
Curr Opin Support Palliat Care. 2014 Jun;8(2):143-51
pubmed: 24752199
Neurology. 2001 May 22;56(10):1371-7
pubmed: 11376190
Brain. 2018 Feb 1;141(2):357-364
pubmed: 29346515
Endocrine. 2009 Feb;35(1):11-7
pubmed: 18979202
Int J Endocrinol. 2018 Mar 15;2018:8641942
pubmed: 29736170
Muscle Nerve. 2007 May;35(5):591-8
pubmed: 17221881
Rev Diabet Stud. 2015 Spring-Summer;12(1-2):29-47
pubmed: 26676660
EBioMedicine. 2015 Aug 04;2(10):1386-93
pubmed: 26629533
Diabetes Care. 2007 Mar;30(3):655-9
pubmed: 17327336
Diabetes Care. 2006 Dec;29(12):2664-9
pubmed: 17130202
Brain Res Bull. 2013 Jul;96:39-44
pubmed: 23644033
Diabetologia. 1984 Dec;27(6):563-7
pubmed: 6530051
Diabetologia. 1993 Dec;36(12):1266-74
pubmed: 8307254
Pain. 2018 Mar;159(3):469-480
pubmed: 29176367
Mol Neurobiol. 2014 Feb;49(1):536-46
pubmed: 23990376
Neuron. 2017 Mar 22;93(6):1296-1313
pubmed: 28334605
J Neurosci. 2011 Sep 28;31(39):13728-38
pubmed: 21957236
Nat Med. 1996 Jun;2(6):703-7
pubmed: 8640566
Curr Drug Metab. 2016;17(4):359-67
pubmed: 26965039
Diabetes. 2017 May;66(5):1380-1390
pubmed: 28202580
Endocr Rev. 2019 Feb 1;40(1):153-192
pubmed: 30256929
Diabet Med. 2015 Jun;32(6):778-85
pubmed: 25761542