PGC-1α, Sirtuins and PARPs in Huntington's Disease and Other Neurodegenerative Conditions: NAD+ to Rule Them All.

Animals Humans Mitochondria / metabolism NAD / metabolism Neurodegenerative Diseases / metabolism Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha / metabolism Poly (ADP-Ribose) Polymerase-1 / metabolism Sirtuins / metabolism
Huntington’s disease NAD+ Nicotinamide Riboside PARPs PGC-1 alpha Sirtruins

Journal

Neurochemical research
ISSN: 1573-6903
Titre abrégé: Neurochem Res
Pays: United States
ID NLM: 7613461

Informations de publication

Date de publication:
Oct 2019
Historique:
received: 28 01 2019
accepted: 02 05 2019
revised: 02 05 2019
pubmed: 9 5 2019
medline: 23 2 2020
entrez: 9 5 2019
Statut: ppublish

Résumé

In this review, we summarize the available published information on the neuroprotective effects of increasing nicotinamide adenine dinucleotide (NAD

Identifiants

DOI: 10.1007/s11064-019-02809-1 PMID: 31065944
pubmed: 31065944
doi: 10.1007/s11064-019-02809-1
pii: 10.1007/s11064-019-02809-1
doi:

Substances chimiques

Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha 0
NAD 0U46U6E8UK
Poly (ADP-Ribose) Polymerase-1 EC 2.4.2.30
Sirtuins EC 3.5.1.-

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

2423-2434

Subventions

Organisme : NINDS NIH HHS
ID : R01 NS086746
Pays : United States
Organisme : NINDS NIH HHS
ID : 5R01NS086746-04
Pays : United States

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Auteurs

Alejandro Lloret (A)

Feil Family Brain and Mind Research Institute, Weill Cornell Medical College, 1400 York Street, 5th Floor, Room A-501, New York, NY, 10065, USA. alejandro.lloret@neucyte.com.
NeuCyte Pharmaceuticals, 1561 Industrial Road, San Carlos, CA, 94070, USA. alejandro.lloret@neucyte.com.
ORCID: 0000-0003-3904-9664

M Flint Beal (MF)

Feil Family Brain and Mind Research Institute, Weill Cornell Medical College, 1400 York Street, 5th Floor, Room A-501, New York, NY, 10065, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › PGC-1α, Sirtuins and PARPs in Huntington's...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › PGC-1α, Sirtuins and PARPs in Huntington's...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › PGC-1α, Sirtuins and PARPs in Huntington's...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › NAD › PGC-1α, Sirtuins and PARPs in Huntington's...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › PGC-1α, Sirtuins and PARPs in Huntington's...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Coactivateurs de récepteurs nucléaires › Coactivateur 1-alpha du récepteur gamma activé par les proliférateurs de peroxysomes › PGC-1α, Sirtuins and PARPs in Huntington's...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Glycosyltransferase › Pentosyltransferases › ADP ribose transferases › Poly(ADP-ribose) polymerases › Poly (ADP-Ribose) polymerase-1 › PGC-1α, Sirtuins and PARPs in Huntington's...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Sirtuines › PGC-1α, Sirtuins and PARPs in Huntington's...