The pericyte microenvironment during vascular development.
endothelial cells
pericytes
vascular morphogenesis
Journal
Microcirculation (New York, N.Y. : 1994)
ISSN: 1549-8719
Titre abrégé: Microcirculation
Pays: United States
ID NLM: 9434935
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
31
08
2018
revised:
29
04
2019
accepted:
03
05
2019
pubmed:
9
5
2019
medline:
22
5
2020
entrez:
9
5
2019
Statut:
ppublish
Résumé
Vascular pericytes provide critical contributions to the formation and integrity of the blood vessel wall within the microcirculation. Pericytes maintain vascular stability and homeostasis by promoting endothelial cell junctions and depositing extracellular matrix (ECM) components within the vascular basement membrane, among other vital functions. As their importance in sustaining microvessel health within various tissues and organs continues to emerge, so does their role in a number of pathological conditions including cancer, diabetic retinopathy, and neurological disorders. Here, we review vascular pericyte contributions to the development and remodeling of the microcirculation, with a focus on the local microenvironment during these processes. We discuss observations of their earliest involvement in vascular development and essential cues for their recruitment to the remodeling endothelium. Pericyte involvement in the angiogenic sprouting context is also considered with specific attention to crosstalk with endothelial cells such as through signaling regulation and ECM deposition. We also address specific aspects of the collective cell migration and dynamic interactions between pericytes and endothelial cells during angiogenic sprouting. Lastly, we discuss pericyte contributions to mechanisms underlying the transition from active vessel remodeling to the maturation and quiescence phase of vascular development.
Identifiants
pubmed: 31066166
doi: 10.1111/micc.12554
pmc: PMC6834874
mid: NIHMS1028439
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12554Subventions
Organisme : NHLBI NIH HHS
ID : R00 HL105779
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL132236
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL146596
Pays : United States
Organisme : NHLBI NIH HHS
ID : R56 HL133826
Pays : United States
Informations de copyright
© 2019 John Wiley & Sons Ltd.
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