Design, Synthesis, and Preliminary Studies of Spiro-isoxazoline-peroxides against Human Cytomegalovirus and Glioblastoma ∥.
Antineoplastic Agents
/ chemical synthesis
Antiviral Agents
/ chemical synthesis
Brain Neoplasms
/ drug therapy
Cell Proliferation
/ drug effects
Cytomegalovirus
/ drug effects
Drug Design
Drug Screening Assays, Antitumor
Glioblastoma
/ drug therapy
Humans
Isoxazoles
/ chemistry
Microbial Sensitivity Tests
Molecular Structure
Peroxides
/ chemistry
Spiro Compounds
/ chemistry
Tumor Cells, Cultured
Journal
The Journal of organic chemistry
ISSN: 1520-6904
Titre abrégé: J Org Chem
Pays: United States
ID NLM: 2985193R
Informations de publication
Date de publication:
07 06 2019
07 06 2019
Historique:
pubmed:
9
5
2019
medline:
8
7
2020
entrez:
9
5
2019
Statut:
ppublish
Résumé
The association between glioblastoma (GBM) and human cytomegalovirus (HCMV) infection has been the intensely debated topic over the decades for developing new therapeutic options. In this regard, the peroxides from natural and synthetic sources served as potential antiviral and anticancer agents in the past. Herein, a concise and efficient strategy has been demonstrated to access a novel class of peroxides containing a spiro-isoxazoline to primarily investigate the biological activities. The synthetic compounds were evaluated for in vitro antiviral and antiproliferative activity against HCMV and glioblastoma cell line (GBM6), respectively. While compound 13m showed moderate anti-CMV activity (IC
Identifiants
pubmed: 31066280
doi: 10.1021/acs.joc.9b00746
doi:
Substances chimiques
Antineoplastic Agents
0
Antiviral Agents
0
Isoxazoles
0
Peroxides
0
Spiro Compounds
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM