When All Else Fails, Listen to the Patient: A Viewpoint on the Use of Ecological Momentary Assessment in Clinical Trials.
controlled clinical trial
ecological momentary assessment
health technology
mental health
psychiatry
Journal
JMIR mental health
ISSN: 2368-7959
Titre abrégé: JMIR Ment Health
Pays: Canada
ID NLM: 101658926
Informations de publication
Date de publication:
21 Apr 2019
21 Apr 2019
Historique:
received:
07
08
2018
accepted:
03
04
2019
revised:
05
02
2019
entrez:
9
5
2019
pubmed:
9
5
2019
medline:
9
5
2019
Statut:
epublish
Résumé
A major problem in mental health clinical trials, such as depression, is low assay sensitivity in primary outcome measures. This has contributed to clinical trial failures, resulting in the exodus of the pharmaceutical industry from the Central Nervous System space. This reduced assay sensitivity in psychiatry outcome measures stems from inappropriately broad measures, recall bias, and poor interrater reliability. Limitations in the ability of traditional measures to differentiate between the trait versus state-like nature of individual depressive symptoms also contributes to measurement error in clinical trials. In this viewpoint, we argue that ecological momentary assessment (EMA)-frequent, real time, in-the-moment assessments of outcomes, delivered via smartphone-can both overcome these psychometric challenges and reduce clinical trial failures by increasing assay sensitivity and minimizing recall and rater bias. Used in this manner, EMA has the potential to further our understanding of treatment response by allowing for the assessment of dynamic interactions between treatment and distinct symptom response.
Identifiants
pubmed: 31066701
pii: v6i5e11845
doi: 10.2196/11845
pmc: PMC6524455
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e11845Informations de copyright
©Aaron M Mofsen, Thomas L Rodebaugh, Ginger E Nicol, Colin A Depp, J Philip Miller, Eric J Lenze. Originally published in JMIR Mental Health (http://mental.jmir.org), 21.04.2019.
Références
Acta Psychiatr Scand. 1975 Mar;51(3):161-70
pubmed: 1136841
Curr Control Trials Cardiovasc Med. 2000;1(1):19-21
pubmed: 11714400
Hypertension. 2001 Dec 1;38(6):E28-32
pubmed: 11751742
JAMA. 2002 Apr 10;287(14):1840-7
pubmed: 11939870
J Clin Psychiatry. 2002 Jun;63(6):477-85
pubmed: 12088158
Psychother Psychosom. 2003 May-Jun;72(3):115-27
pubmed: 12707478
J Neurol Neurosurg Psychiatry. 1960 Feb;23:56-62
pubmed: 14399272
Lancet. 2003 Oct 11;362(9391):1225-30
pubmed: 14568747
Health Law Rev. 2002;10(2):30-2
pubmed: 15739309
J Public Health (Oxf). 2005 Sep;27(3):281-91
pubmed: 15870099
Pers Soc Psychol Bull. 2005 Oct;31(10):1340-6
pubmed: 16143666
N Engl J Med. 2006 Jun 1;354(22):2368-74
pubmed: 16738273
Dialogues Clin Neurosci. 2006;8(2):207-15
pubmed: 16889106
Emotion. 2006 Aug;6(3):383-91
pubmed: 16938080
J Clin Psychopharmacol. 2007 Feb;27(1):1-5
pubmed: 17224705
Neuropsychopharmacology. 2009 Mar;34(4):923-31
pubmed: 18496519
Contemp Clin Trials. 2008 Nov;29(6):867-77
pubmed: 18606249
Am Heart J. 1991 Mar;121(3 Pt 2):999-1006
pubmed: 1996533
J Clin Psychopharmacol. 2010 Apr;30(2):193-7
pubmed: 20520295
Science. 2010 Jul 30;329(5991):502-4
pubmed: 20671165
J Appl Meas. 2010;11(3):304-14
pubmed: 20847477
Philos Trans R Soc Lond B Biol Sci. 2011 Jun 27;366(1572):1879-88
pubmed: 21576145
Eur Neuropsychopharmacol. 2011 Jul;21(7):495-9
pubmed: 21684455
Depress Anxiety. 2012 Dec;29(12):1043-9
pubmed: 22933451
J Clin Psychiatry. 2012 Oct;73(10):1300-6
pubmed: 23140647
Annu Rev Clin Psychol. 2013;9:151-76
pubmed: 23157450
Am J Psychiatry. 2013 Jul;170(7):723-33
pubmed: 23318413
Neurology. 2013 Mar 12;80(11 Suppl 3):S2-6
pubmed: 23479538
Neurosci Biobehav Rev. 2013 Dec;37(10 Pt 1):2438-44
pubmed: 23563062
PLoS One. 2013 Apr 04;8(4):e60188
pubmed: 23593171
Cerebrum. 2013 Apr 02;2013:5
pubmed: 23720708
Nat Rev Neurosci. 2013 Sep;14(9):649-658
pubmed: 23942467
Lancet. 2014 Jan 11;383(9912):176-85
pubmed: 24411646
Psychiatry Res. 2014 Dec 15;220(1-2):287-93
pubmed: 25070177
Neuron. 2014 Nov 5;84(3):546-53
pubmed: 25442933
Mol Psychiatry. 2016 Apr;21(4):523-30
pubmed: 25917369
J Clin Psychopharmacol. 2015 Oct;35(5):566-73
pubmed: 26244381
Front Psychiatry. 2015 Aug 21;6:117
pubmed: 26347663
World Psychiatry. 2015 Oct;14(3):294-300
pubmed: 26407778
Science. 1989 Mar 31;243(4899):1668-74
pubmed: 2648573
JMIR Ment Health. 2014 Dec 23;1(1):e5
pubmed: 26543905
Health Psychol. 2015 Dec;34S:1220-8
pubmed: 26651463
J Affect Disord. 2016 Mar 15;193:145-50
pubmed: 26773907
Psychol Assess. 2016 Nov;28(11):1354-1367
pubmed: 26821198
J Psychiatr Res. 2016 Apr;75:116-23
pubmed: 26851494
JAMA Psychiatry. 2016 Jul 1;73(7):675-84
pubmed: 27304433
Ann N Y Acad Sci. 2016 Jul;1375(1):3-18
pubmed: 27384501
Evid Based Ment Health. 2016 Aug;19(3):86-9
pubmed: 27443678
J Clin Psychopharmacol. 2016 Oct;36(5):453-6
pubmed: 27525966
N Engl J Med. 2016 Sep 1;375(9):861-70
pubmed: 27579636
Emot Rev. 2015 Oct;7(4):355-361
pubmed: 27617032
Neuropsychopharmacology. 2017 Mar;42(4):844-853
pubmed: 27681442
J Affect Disord. 2017 Jan 15;208:191-197
pubmed: 27792962
Health Psychol Rev. 2017 Jun;11(2):103-121
pubmed: 28110627
Stress. 2017 Jan;20(1):95-111
pubmed: 28124571
JAMA Psychiatry. 2017 Apr 1;74(4):370-378
pubmed: 28241180
Am J Psychiatry. 2017 Oct 1;174(10):927-942
pubmed: 28541090
Am J Psychiatry. 2017 Sep 1;174(9):829-831
pubmed: 28859511
Multivariate Behav Res. 2018 Nov-Dec;53(6):820-841
pubmed: 29624092
PLoS One. 2018 Sep 7;13(9):e0203574
pubmed: 30192853
Clin Pharmacol Ther. 2019 May;105(5):1164-1174
pubmed: 30460996
Psychol Assess. 2019 Apr;31(4):516-531
pubmed: 30869961
Br J Psychiatry. 1979 Apr;134:382-9
pubmed: 444788
Psychol Bull. 1999 Jan;125(1):3-30
pubmed: 9990843