Structural Covariance Reveals Alterations in Control and Salience Network Integrity in Chronic Schizophrenia.
magnetic resonance imaging
partial least squares
psychosis
structural network abnormalities
Journal
Cerebral cortex (New York, N.Y. : 1991)
ISSN: 1460-2199
Titre abrégé: Cereb Cortex
Pays: United States
ID NLM: 9110718
Informations de publication
Date de publication:
17 12 2019
17 12 2019
Historique:
received:
20
04
2015
revised:
07
02
2019
accepted:
07
02
2019
pubmed:
9
5
2019
medline:
5
11
2020
entrez:
9
5
2019
Statut:
ppublish
Résumé
Schizophrenia (SCZ) is recognized as a disorder of distributed brain dysconnectivity. While progress has been made delineating large-scale functional networks in SCZ, little is known about alterations in grey matter integrity of these networks. We used a multivariate approach to identify the structural covariance of the salience, default, motor, visual, fronto-parietal control, and dorsal attention networks. We derived individual scores reflecting covariance in each structural image for a given network. Seed-based multivariate analyses were conducted on structural images in a discovery (n = 90) and replication (n = 74) sample of SCZ patients and healthy controls. We first validated patterns across all networks, consistent with well-established functional connectivity reports. Next, across two SCZ samples, we found reliable and robust reductions in structural integrity of the fronto-parietal control and salience networks, but not default, dorsal attention, motor and sensory networks. Well-powered exploratory analyses failed to identify relationships with symptoms. These findings provide evidence of selective structural decline in associative networks in SCZ. Such decline may be linked with recently identified functional disturbances in associative networks, providing more sensitive multi-modal network-level probes in SCZ. Absence of symptom effects suggests that identified disturbances may underlie a trait-type marker in SCZ.
Identifiants
pubmed: 31066899
pii: 5486490
doi: 10.1093/cercor/bhz064
pmc: PMC6918933
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5269-5284Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH112189
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH108590
Pays : United States
Informations de copyright
© The Author(s) 2019. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Références
Nat Neurosci. 2014 Dec;17(12):1661-3
pubmed: 25383900
Am J Psychiatry. 2006 Nov;163(11):1960-8
pubmed: 17074948
Neuroimage. 2018 Oct 1;179:357-372
pubmed: 29782994
Can J Psychiatry. 2007 Mar;52(3):158-66
pubmed: 17479523
Proc Natl Acad Sci U S A. 2014 May 20;111(20):7438-43
pubmed: 24799682
Schizophr Res. 2004 Dec 15;72(1):29-39
pubmed: 15531405
Cell Mol Neurobiol. 2006 Jul-Aug;26(4-6):365-84
pubmed: 16773445
Neuroimage. 2013 Oct 15;80:426-44
pubmed: 23643999
Nat Rev Neurosci. 2013 May;14(5):322-36
pubmed: 23531697
Front Hum Neurosci. 2012 May 23;6:137
pubmed: 22654746
Biol Psychiatry. 1999 Sep 1;46(5):627-49
pubmed: 10472416
Neurosci Lett. 2006 Jan 9;392(1-2):16-21
pubmed: 16171947
Nat Neurosci. 2013 Jul;16(7):832-7
pubmed: 23799476
Neuron. 2009 Apr 16;62(1):42-52
pubmed: 19376066
Front Hum Neurosci. 2012 Feb 24;6:27
pubmed: 22375114
Schizophr Bull. 2014 Nov;40(6):1227-43
pubmed: 25031221
Biol Psychiatry. 2015 Jun 1;77(11):989-96
pubmed: 25524754
Schizophr Bull. 2014 Sep;40(5):1105-16
pubmed: 24366718
J Neurosci. 2008 Sep 10;28(37):9239-48
pubmed: 18784304
Cereb Cortex. 2014 Dec;24(12):3116-30
pubmed: 23825317
Biol Psychiatry. 2011 Dec 15;70(12):1159-68
pubmed: 21861986
Neuroimage. 2013 Oct 15;80:105-24
pubmed: 23668970
Am J Psychiatry. 2012 Oct;169(10):1092-9
pubmed: 23032387
Trends Cogn Sci. 2012 Jan;16(1):27-34
pubmed: 22169777
Biol Psychiatry. 2011 May 15;69(10):967-73
pubmed: 21193174
Neuroimage. 2011 Oct 15;58(4):1158-68
pubmed: 21763438
Neurobiol Aging. 2012 May;33(5):899-913
pubmed: 20724031
Neuroimage. 2014 Oct 1;99:215-25
pubmed: 24857714
Schizophr Bull. 1987;13(2):261-76
pubmed: 3616518
Cereb Cortex. 2013 Jan;23(1):127-38
pubmed: 22275481
Arch Gen Psychiatry. 1994 Feb;51(2):124-31
pubmed: 7905258
Front Psychiatry. 2013 Dec 24;4:169
pubmed: 24399974
Biol Psychiatry. 2006 May 15;59(10):929-39
pubmed: 16427028
Brain Struct Funct. 2015 Jul;220(4):2059-71
pubmed: 24771247
Biol Psychiatry. 2010 Feb 1;67(3):255-62
pubmed: 19897178
Schizophr Bull. 1998;24(3):425-35
pubmed: 9718634
J Neurophysiol. 2006 Dec;96(6):3517-31
pubmed: 16899645
Neuroimage. 2012 Oct 1;62(4):2296-314
pubmed: 22387165
Int Rev Neurobiol. 2005;67:285-323
pubmed: 16291026
Brain Imaging Behav. 2019 Apr;13(2):493-502
pubmed: 29728906
Neuropsychopharmacology. 1996 Jan;14(1):1-17
pubmed: 8719025
Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1279-84
pubmed: 19164577
Brain Struct Funct. 2017 Nov;222(8):3833-3845
pubmed: 28474183
Neuroimage. 2011 May 15;56(2):455-75
pubmed: 20656037
Neuron. 2011 Nov 17;72(4):665-78
pubmed: 22099467
BMC Psychiatry. 2014 Apr 02;14:99
pubmed: 24693962
Psychol Med. 2019 Feb;49(3):412-420
pubmed: 29729682
Curr Opin Neurobiol. 2013 Apr;23(2):283-90
pubmed: 23228430
Neuroimage. 2007 Oct 15;38(1):95-113
pubmed: 17761438
Hum Brain Mapp. 2013 Sep;34(9):2302-12
pubmed: 22461278
Arch Gen Psychiatry. 2000 Aug;57(8):761-8
pubmed: 10920464
Neuroimage. 2018 May 1;171:256-267
pubmed: 29274746
Psychiatry Res. 2010 May 30;182(2):123-33
pubmed: 20456929
Neuroimage. 2011 May 1;56(1):235-45
pubmed: 21238595
Netw Neurosci. 2017 Oct 01;1(3):302-323
pubmed: 29855624
Schizophr Bull. 2012 Sep;38(5):1050-62
pubmed: 21436318
Biol Psychiatry. 2013 Mar 15;73(6):565-73
pubmed: 22980587
Schizophr Bull. 2014 May;40(3):523-31
pubmed: 24609453
J Neurosci. 2010 Mar 10;30(10):3777-81
pubmed: 20220012
Schizophr Res. 2017 Jan;179:91-96
pubmed: 27720314
Neuroimage. 2014 Oct 1;99:269-80
pubmed: 24844743
JAMA Psychiatry. 2014 Feb;71(2):109-18
pubmed: 24306091
Neuroimage Clin. 2014 May 09;4:779-87
pubmed: 24936428
J Neurosci. 2013 Sep 18;33(38):15226-34
pubmed: 24048852
Biol Psychiatry. 2011 Jul 1;70(1):43-50
pubmed: 21496789
Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):18191-6
pubmed: 20921389
Hum Brain Mapp. 2018 Feb;39(2):644-661
pubmed: 29105239
Neuroimage. 2013 Dec;83:418-30
pubmed: 23777757
Neuron. 2013 Apr 10;78(1):81-93
pubmed: 23583108
Neurotox Res. 2006 Dec;10(3-4):235-52
pubmed: 17197373
Cereb Cortex. 2013 Sep;23(9):2072-85
pubmed: 22784607
J Neurophysiol. 2011 Sep;106(3):1125-65
pubmed: 21653723
Schizophr Res. 2011 Apr;127(1-3):46-57
pubmed: 21300524
Neuron. 2013 Aug 21;79(4):814-28
pubmed: 23972602
J Psychiatr Res. 2015 Dec;71:89-96
pubmed: 26458012