The Structural Biology of Bcl-x

Animals Binding Sites Humans Protein Binding Protein Multimerization Tumor Suppressor Protein p53 / chemistry bcl-X Protein / chemistry
BH3 domain BH3-mimetic BH3-only Bcl-2 Bcl-xL apoptosis pro-survival structural biology

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
07 May 2019
Historique:
received: 10 04 2019
revised: 02 05 2019
accepted: 06 05 2019
entrez: 10 5 2019
pubmed: 10 5 2019
medline: 4 9 2019
Statut: epublish

Résumé

Interactions between the pro-survival and pro-apoptotic members of the Bcl-2 family of proteins dictate whether a cell lives or dies. Much of our knowledge of the molecular details of these interactions has come from biochemical and structural studies on the pro-survival protein Bcl-x

Identifiants

DOI: 10.3390/ijms20092234 PMID: 31067648 PMC: PMC6540150
pubmed: 31067648
pii: ijms20092234
doi: 10.3390/ijms20092234
pmc: PMC6540150
pii:
doi:

Substances chimiques

Tumor Suppressor Protein p53 0
bcl-X Protein 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : National Health and Medical Research Council
ID : GNT1122829 and GNT1157551
Organisme : Australian Research Council
ID : FT150100212

Références

Cell. 1999 Mar 5;96(5):615-24
pubmed: 10089877
Mol Cell Biol. 1999 Oct;19(10):6673-81
pubmed: 10490606
Biochemistry. 2000 Sep 12;39(36):11024-33
pubmed: 10998239
Cell. 2000 Nov 10;103(4):645-54
pubmed: 11106734
Protein Sci. 2000 Dec;9(12):2528-34
pubmed: 11206074
Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3012-7
pubmed: 11248023
EMBO J. 2003 Apr 1;22(7):1497-507
pubmed: 12660157
Immunity. 2003 Sep;19(3):341-52
pubmed: 14499110
J Biol Chem. 2004 Jan 16;279(3):2159-65
pubmed: 14534311
FEBS Lett. 2004 Feb 13;559(1-3):171-4
pubmed: 14960327
Science. 2004 Feb 13;303(5660):1010-4
pubmed: 14963330
Proc Natl Acad Sci U S A. 2004 Sep 14;101(37):13590-5
pubmed: 15342906
J Biol Chem. 2005 Feb 11;280(6):4738-44
pubmed: 15550399
Mol Cell. 2005 Feb 4;17(3):393-403
pubmed: 15694340
Nature. 2005 Jun 2;435(7042):677-81
pubmed: 15902208
Science. 2005 Sep 9;309(5741):1732-5
pubmed: 16151013
Cell. 2005 Sep 23;122(6):927-39
pubmed: 16179260
J Mol Biol. 2006 Feb 17;356(2):367-81
pubmed: 16368107
Cell Death Differ. 2007 Jan;14(1):128-36
pubmed: 16645638
Mol Cell. 2006 Oct 20;24(2):199-210
pubmed: 17052454
Mol Cell. 2006 Dec 8;24(5):677-688
pubmed: 17157251
J Am Chem Soc. 2007 Jan 10;129(1):139-54
pubmed: 17199293
Biochemistry. 2007 Jan 23;46(3):734-40
pubmed: 17223694
J Med Chem. 2007 Feb 22;50(4):641-62
pubmed: 17256834
J Biol Chem. 2007 Apr 27;282(17):13123-32
pubmed: 17337444
Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6217-22
pubmed: 17389404
Cell Death Differ. 2007 Sep;14(9):1711-3
pubmed: 17572662
J Mol Biol. 2007 Sep 7;372(1):223-35
pubmed: 17659302
PLoS Pathog. 2008 Feb 8;4(2):e25
pubmed: 18248095
Angew Chem Int Ed Engl. 2008;47(15):2853-6
pubmed: 18330876
Cancer Res. 2008 May 1;68(9):3421-8
pubmed: 18451170
Nature. 2008 Oct 23;455(7216):1076-81
pubmed: 18948948
Arch Biochem Biophys. 2009 Apr 1;484(1):46-54
pubmed: 19161970
Angew Chem Int Ed Engl. 2009;48(24):4318-22
pubmed: 19229915
J Biol Chem. 2009 Oct 30;284(44):30508-17
pubmed: 19726685
Biochem Biophys Res Commun. 2010 Apr 9;394(3):515-21
pubmed: 20206602
Nat Chem Biol. 2010 Aug;6(8):595-601
pubmed: 20562877
Cell Res. 2011 Apr;21(4):627-41
pubmed: 21060336
J Biol Chem. 2011 Mar 4;286(9):7123-31
pubmed: 21199865
J Med Chem. 2011 Mar 24;54(6):1914-26
pubmed: 21366295
Biochem J. 2011 Sep 1;438(2):291-301
pubmed: 21639858
Chembiochem. 2011 Sep 5;12(13):2025-32
pubmed: 21744457
J Am Chem Soc. 2012 Jan 11;134(1):315-23
pubmed: 22040025
J Med Chem. 2012 May 24;55(10):4664-82
pubmed: 22448988
J Am Chem Soc. 2012 May 9;134(18):7644-7
pubmed: 22515821
Bioorg Med Chem Lett. 2012 Jun 15;22(12):3951-6
pubmed: 22608393
ACS Chem Biol. 2013 Feb 15;8(2):297-302
pubmed: 23151250
Nat Med. 2013 Feb;19(2):202-8
pubmed: 23291630
Nat Chem Biol. 2013 Mar;9(3):163-8
pubmed: 23340338
Cell. 2013 Jan 31;152(3):519-31
pubmed: 23374347
Nat Chem Biol. 2013 Jun;9(6):390-7
pubmed: 23603658
Chembiochem. 2013 Sep 2;14(13):1564-72
pubmed: 23929624
Cell Death Differ. 2014 Feb;21(2):196-205
pubmed: 24162660
J Med Chem. 2013 Dec 12;56(23):9635-45
pubmed: 24215352
Nat Rev Mol Cell Biol. 2014 Jan;15(1):49-63
pubmed: 24355989
ACS Chem Biol. 2014 Mar 21;9(3):831-7
pubmed: 24358963
J Med Chem. 2014 Feb 27;57(4):1323-43
pubmed: 24456288
Nat Struct Mol Biol. 2014 Jun;21(6):535-43
pubmed: 24814347
ACS Med Chem Lett. 2014 Mar 21;5(6):662-7
pubmed: 24944740
Mol Cell. 2014 Sep 18;55(6):938-946
pubmed: 25175025
ACS Med Chem Lett. 2014 Aug 26;5(10):1088-93
pubmed: 25313317
J Biol Chem. 2014 Dec 26;289(52):36001-17
pubmed: 25371206
J Biol Chem. 2015 Apr 3;290(14):9150-61
pubmed: 25681439
J Mol Biol. 2015 Jul 3;427(13):2262-70
pubmed: 25731750
Sci Rep. 2015 Apr 15;5:9641
pubmed: 25872771
J Mol Biol. 2015 Jul 3;427(13):2257-61
pubmed: 25896456
Proteins. 2015 Jul;83(7):1262-72
pubmed: 25907960
ACS Chem Biol. 2015 Jul 17;10(7):1667-75
pubmed: 25946900
Sci Rep. 2015 May 29;5:10609
pubmed: 26023881
Cell Death Dis. 2015 Jul 02;6:e1804
pubmed: 26136077
Sci Rep. 2016 Jan 27;6:19725
pubmed: 26813996
Genes Dev. 2016 May 15;30(10):1240-50
pubmed: 27198225
Carcinogenesis. 2017 Jun 1;38(6):579-587
pubmed: 28203756
Cell. 1986 Oct 10;47(1):19-28
pubmed: 2875799
Chem Sci. 2016 Jun 1;7(6):3694-3702
pubmed: 28970875
Mol Cell. 2017 Nov 16;68(4):659-672.e9
pubmed: 29149594
Structure. 2018 Jan 2;26(1):153-160.e4
pubmed: 29276033
Chemistry. 2018 Apr 11;24(21):5493-5499
pubmed: 29457664
Nat Chem Biol. 2018 May;14(5):458-465
pubmed: 29507390
Nature. 2018 Jun;558(7708):136-140
pubmed: 29849149
J Biol Chem. 2018 Dec 21;293(51):19546-19558
pubmed: 30429221
Autophagy. 2019 May;15(5):785-795
pubmed: 30626284
Elife. 2019 Mar 12;8:null
pubmed: 30860026
Proc Natl Acad Sci U S A. 1986 Jul;83(14):5214-8
pubmed: 3523487
Science. 1984 Nov 30;226(4678):1097-9
pubmed: 6093263
Oncogene. 1995 Nov 2;11(9):1921-8
pubmed: 7478623
Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3516-20
pubmed: 7682708
Nature. 1995 Apr 20;374(6524):731-3
pubmed: 7715729
Nature. 1995 Apr 20;374(6524):733-6
pubmed: 7715730
Nature. 1995 Apr 20;374(6524):736-9
pubmed: 7715731
Nature. 1994 May 26;369(6478):321-3
pubmed: 8183370
Trends Biochem Sci. 1993 Oct;18(10):391-5
pubmed: 8256289
J Immunol. 1993 Aug 15;151(4):1979-88
pubmed: 8345191
Cell. 1993 Aug 27;74(4):597-608
pubmed: 8358789
Cell. 1993 Aug 27;74(4):609-19
pubmed: 8358790
EMBO J. 1995 Nov 15;14(22):5589-96
pubmed: 8521816
Nature. 1996 May 23;381(6580):335-41
pubmed: 8692274
Oncogene. 1996 Aug 15;13(4):665-75
pubmed: 8761287
Science. 1997 Feb 14;275(5302):983-6
pubmed: 9020082
J Biol Chem. 1997 Oct 31;272(44):27886-92
pubmed: 9346936
J Biol Chem. 1997 Dec 5;272(49):30866-72
pubmed: 9388232

Auteurs

Erinna F Lee (EF)

Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Victoria 3086, Australia. Erinna.Lee@latrobe.edu.au.
Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria 3084, Australia. Erinna.Lee@latrobe.edu.au.
School of Cancer Medicine, La Trobe University, Melbourne, Victoria 3084, Australia. Erinna.Lee@latrobe.edu.au.
ORCID: 0000-0003-1255-9808

W Douglas Fairlie (WD)

Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Victoria 3086, Australia. doug.fairlie@onjcri.org.au.
Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria 3084, Australia. doug.fairlie@onjcri.org.au.
School of Cancer Medicine, La Trobe University, Melbourne, Victoria 3084, Australia. doug.fairlie@onjcri.org.au.
ORCID: 0000-0002-2498-1160

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › The Structural Biology of Bcl-x
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › The Structural Biology of Bcl-x
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The Structural Biology of Bcl-x
questionsmedicales.fr › Métabolisme › Liaison aux protéines › The Structural Biology of Bcl-x
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Multimérisation de protéines › The Structural Biology of Bcl-x
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Phosphoprotéines › Protéine p53 suppresseur de tumeur › The Structural Biology of Bcl-x
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines régulatrices de l'apoptose › Protéine bcl-X › The Structural Biology of Bcl-x