Comparison of Vitex agnus-castus Extracts with Placebo in Reducing Menopausal Symptoms: A Randomized Double-Blind Study.
Menopause
Placebo Effect
Vitex agnus-castus Extract
Women
Journal
Korean journal of family medicine
ISSN: 2005-6443
Titre abrégé: Korean J Fam Med
Pays: Korea (South)
ID NLM: 101502902
Informations de publication
Date de publication:
Nov 2019
Nov 2019
Historique:
received:
18
05
2018
accepted:
05
06
2018
pubmed:
10
5
2019
medline:
10
5
2019
entrez:
10
5
2019
Statut:
ppublish
Résumé
Menopausal symptoms have remarkable negative effects on women's quality of life, justifying the need to assess various therapeutic options. This research aimed to determine the effectiveness of Vitex agnus-castus extracts in alleviating menopausal symptoms in comparison with that of placebo. This study was a randomized controlled double-blind clinical trial with a study group of 52 women referred to a clinic in Kermanshah in 2017. The participants were randomly divided into two groups: Vitex group (26 subjects) and placebo group (26 subjects). Menopausal symptoms were assessed using the Greene Scale before and 8 weeks after the intervention. After the intervention, the mean scores for total menopausal disorder, anxiety, and vasomotor dysfunction were significantly lower in the Vitex group than in the placebo group (P<0.05). The mean scores of the variables of somatic complications, depression, and sexual dysfunction did not show significant differences between the Vitex and placebo groups (P>0.05). Administration of Vitex agnus-castus extracts as a phytoestrogenic medicine can alleviate menopausal symptoms in women.
Sections du résumé
BACKGROUND
BACKGROUND
Menopausal symptoms have remarkable negative effects on women's quality of life, justifying the need to assess various therapeutic options. This research aimed to determine the effectiveness of Vitex agnus-castus extracts in alleviating menopausal symptoms in comparison with that of placebo.
METHODS
METHODS
This study was a randomized controlled double-blind clinical trial with a study group of 52 women referred to a clinic in Kermanshah in 2017. The participants were randomly divided into two groups: Vitex group (26 subjects) and placebo group (26 subjects). Menopausal symptoms were assessed using the Greene Scale before and 8 weeks after the intervention.
RESULTS
RESULTS
After the intervention, the mean scores for total menopausal disorder, anxiety, and vasomotor dysfunction were significantly lower in the Vitex group than in the placebo group (P<0.05). The mean scores of the variables of somatic complications, depression, and sexual dysfunction did not show significant differences between the Vitex and placebo groups (P>0.05).
CONCLUSION
CONCLUSIONS
Administration of Vitex agnus-castus extracts as a phytoestrogenic medicine can alleviate menopausal symptoms in women.
Identifiants
pubmed: 31067851
pii: kjfm.18.0067
doi: 10.4082/kjfm.18.0067
pmc: PMC6887765
doi:
Types de publication
Journal Article
Langues
eng
Pagination
362-367Subventions
Organisme : Substance Abuse Prevention Research Center
Organisme : Emam Reza Hospital
ID : 96062
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