Methanol extract of Muntingia calabura leaves attenuates CCl
Animals
Antioxidants
/ isolation & purification
Carbon Tetrachloride
Chemical and Drug Induced Liver Injury
/ metabolism
Dose-Response Relationship, Drug
Flavonoids
/ isolation & purification
Male
Malvales
/ chemistry
Phytochemicals
/ isolation & purification
Plant Extracts
/ isolation & purification
Plant Leaves
/ chemistry
Rats, Sprague-Dawley
Volatilization
GCMS
Muntingiaceae
UHPLC-ESI
antioxidant activity
hepatoprotective activity
oxidative stress markers
phytoconstituents
pro-inflammatory mediators
Journal
Pharmaceutical biology
ISSN: 1744-5116
Titre abrégé: Pharm Biol
Pays: England
ID NLM: 9812552
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
entrez:
10
5
2019
pubmed:
10
5
2019
medline:
31
12
2019
Statut:
ppublish
Résumé
Muntingia calabura L. (Muntingiaceae) exerts antioxidant and anti-inflammatory activities, thus, it might be a good hepatoprotective agent. This study investigates the effect of methanol extract of M. calabura leaves (MMCL) on hepatic antioxidant and anti-inflammatory activities in CCl Sprague Dawley rats (n = 6) were treated (p.o.) with 10% DMSO (Groups 1 and 2), 50 mg/kg N-acetylcysteine (Group 3) or, 50, 250, or 500 mg/kg MMCL (Groups 4-6) for 7 consecutive days followed by pretreatment (i.p.) with vehicle (Group 1) or 50% CCl MMCL, at 500 mg/kg, significantly (p < 0.05) ameliorated CCl MMCL ability to attenuate CCl
Identifiants
pubmed: 31068038
doi: 10.1080/13880209.2019.1606836
pmc: PMC6508049
doi:
Substances chimiques
Antioxidants
0
Flavonoids
0
Phytochemicals
0
Plant Extracts
0
Carbon Tetrachloride
CL2T97X0V0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
335-344Références
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