Elevated cerebrospinal fluid total tau in former professional athletes with multiple concussions.
Adult
Aged
Alzheimer Disease
/ cerebrospinal fluid
Amyloid beta-Peptides
/ cerebrospinal fluid
Athletes
Brain Concussion
/ cerebrospinal fluid
Case-Control Studies
Chronic Traumatic Encephalopathy
Cognition
Diffusion Tensor Imaging
Football
/ injuries
Hockey
/ injuries
Humans
Male
Middle Aged
Neuropsychological Tests
Peptide Fragments
/ cerebrospinal fluid
Skiing
/ injuries
Trail Making Test
White Matter
/ diagnostic imaging
tau Proteins
/ cerebrospinal fluid
Journal
Neurology
ISSN: 1526-632X
Titre abrégé: Neurology
Pays: United States
ID NLM: 0401060
Informations de publication
Date de publication:
04 06 2019
04 06 2019
Historique:
received:
21
09
2018
accepted:
01
02
2019
pubmed:
10
5
2019
medline:
24
12
2019
entrez:
10
5
2019
Statut:
ppublish
Résumé
To identify CSF biomarkers that are related to decreased white matter (WM) integrity and poor cognitive performance in former professional athletes with a history of multiple concussions. Concentrations of phosphorylated tau181, total tau (t-tau), and β-amyloid in the CSF were measured in 3 groups: 22 former professional athletes with multiple concussions (mean ± SD age 55.9 ± 12.2 years), 5 healthy controls (age 57.4 ± 5.2 years), and 12 participants (age 60.0 ± 6.6 years) diagnosed with Alzheimer disease (AD). All participants in the former athletes group underwent diffusion tensor imaging to determine WM tract integrity and completed neuropsychological testing. We divided the former athletes group into those with normal (<300 pg/mL) and high (>300 pg/mL) CSF t-tau. CSF t-tau in the former athletes group was significantly higher than in the healthy control group (349.3 ± 182.6 vs 188.8 ± 39.9 pg/mL, Our findings indicate that former athletes with multiple concussions are at increased risk of elevated levels of CSF t-tau and that high CSF t-tau is associated with reduced WM integrity and worse scores on the TMT Part B.
Identifiants
pubmed: 31068482
pii: WNL.0000000000007608
doi: 10.1212/WNL.0000000000007608
pmc: PMC6556099
doi:
Substances chimiques
Amyloid beta-Peptides
0
MAPT protein, human
0
Peptide Fragments
0
amyloid beta-protein (1-42)
0
tau Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2717-e2726Informations de copyright
© 2019 American Academy of Neurology.
Références
Brain. 2006 Nov;129(Pt 11):3035-41
pubmed: 17012293
PLoS One. 2012;7(6):e37720
pubmed: 22701578
Acta Neuropathol. 2015 Dec;130(6):877-89
pubmed: 26518018
Acta Neuropathol. 2016 Jan;131(1):75-86
pubmed: 26667418
Brain. 2005 Nov;128(Pt 11):2556-61
pubmed: 16033781
Arch Neurol. 2009 Mar;66(3):382-9
pubmed: 19273758
Neurology. 2003 May 13;60(9):1457-61
pubmed: 12743231
PLoS One. 2012;7(4):e33606
pubmed: 22496755
Brain. 2009 Mar;132(Pt 3):695-708
pubmed: 19176544
Arch Neurol. 2003 Sep;60(9):1202-6
pubmed: 12975284
J Neuropathol Exp Neurol. 2009 Jul;68(7):709-35
pubmed: 19535999
J Neurotrauma. 2015 Mar 1;32(5):342-52
pubmed: 25177776
Arch Neurol. 2003 Dec;60(12):1696-702
pubmed: 14676043
Neuroscience. 2014 Sep 12;276:206-15
pubmed: 24583036
Front Hum Neurosci. 2014 Jan 31;8:30
pubmed: 24550810
J Clin Exp Neuropsychol. 2000 Aug;22(4):518-28
pubmed: 10923061
Front Neurol. 2016 Sep 19;7:156
pubmed: 27698651
Nat Rev Neurol. 2010 Mar;6(3):131-44
pubmed: 20157306
Alzheimers Dement. 2018 Sep;14(9):1159-1170
pubmed: 30049650
J Neurotrauma. 2018 Mar 1;35(5):719-729
pubmed: 29239265
JAMA. 2009 Jul 22;302(4):385-93
pubmed: 19622817
J Magn Reson Imaging. 2008 Apr;27(4):685-91
pubmed: 18302232
NeuroRx. 2004 Apr;1(2):213-25
pubmed: 15717022
Neurosci Lett. 2001 Jan 19;297(3):187-90
pubmed: 11137759
Neuroscientist. 2019 Feb;25(1):8-21
pubmed: 29283022
J Neurol Neurosurg Psychiatry. 2001 Sep;71(3):401-3
pubmed: 11511720
Radiology. 2013 Jan;266(1):295-303
pubmed: 23151827
Brain Struct Funct. 2016 May;221(4):1911-25
pubmed: 25721800
Nat Rev Neurol. 2013 Apr;9(4):201-10
pubmed: 23399646
Neurology. 2015 Mar 17;84(11):1114-20
pubmed: 25632088
Neurology. 2006 Nov 14;67(9):1600-4
pubmed: 17101890
Arch Clin Neuropsychol. 2004 Mar;19(2):203-14
pubmed: 15010086
J Neurotrauma. 2018 Aug 15;35(16):1929-1941
pubmed: 29644915
Neuroimage Clin. 2013 Apr 10;2:534-541
pubmed: 24049744
Appl Neuropsychol. 2002;9(2):106-9
pubmed: 12214820
Neurology. 1999 Oct 22;53(7):1488-94
pubmed: 10534256
Neurology. 2012 Jan 3;78(1):47-54
pubmed: 22170879
Neurology. 1999 May 12;52(8):1555-62
pubmed: 10331678
Alzheimers Dement. 2015 Jan;11(1):58-69
pubmed: 24795085
Clin Chem. 2001 Oct;47(10):1776-81
pubmed: 11568086
Annu Rev Clin Psychol. 2015;11:309-30
pubmed: 25581233
J Alzheimers Dis. 2007 Nov;12(3):255-60
pubmed: 18057559
Eur J Neurol. 2007 Feb;14(2):168-73
pubmed: 17250725
Neuroimage Clin. 2018 May 14;19:551-558
pubmed: 29984163
Front Hum Neurosci. 2013 May 24;7:222
pubmed: 23745112