The Role of Myeloid-Derived Cells in the Progression of Liver Disease.
Acute Disease
Animals
Cell Differentiation
/ genetics
Chronic Disease
Disease Progression
Disease Susceptibility
Humans
Kupffer Cells
/ immunology
Liver Cirrhosis
/ etiology
Liver Diseases
/ etiology
Liver Neoplasms
/ etiology
Macrophages
/ immunology
Monocytes
/ immunology
Myeloid Cells
/ immunology
Neutrophils
/ immunology
Phenotype
circulating monocytes
cirrhosis
fibrosis
hepatitis (general)
hepatocellular carcinoma
macrophage
myeloid derived suppressor cell (MDSC)
neutrophil (PMN)
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2019
2019
Historique:
received:
13
09
2018
accepted:
08
04
2019
entrez:
10
5
2019
pubmed:
10
5
2019
medline:
2
10
2020
Statut:
epublish
Résumé
Control of homeostasis and rapid response to tissue damage in the liver is orchestrated by crosstalk between resident and infiltrating inflammatory cells. A crucial role for myeloid cells during hepatic injury and repair has emerged where resident Kupffer cells, circulating monocytes, macrophages, dendritic cells and neutrophils control local tissue inflammation and regenerative function to maintain tissue architecture. Studies in humans and rodents have revealed a heterogeneous population of myeloid cells that respond to the local environment by either promoting regeneration or driving the inflammatory processes that can lead to hepatitis, fibrogenesis, and the development of cirrhosis and malignancy. Such plasticity of myeloid cell responses presents unique challenges for therapeutic intervention strategies and a greater understanding of the underlying mechanisms is needed. Here we review the role of myeloid cells in the establishment and progression of liver disease and highlight key pathways that have become the focus for current and future therapeutic strategies.
Identifiants
pubmed: 31068952
doi: 10.3389/fimmu.2019.00893
pmc: PMC6491757
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
893Subventions
Organisme : Medical Research Council
ID : MR/M009157/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0300101
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0300102
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0700301
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0802577
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_14123
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0400496
Pays : United Kingdom
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