The triacylglycerol, hydroxytriolein, inhibits triple negative mammary breast cancer cell proliferation through a mechanism dependent on dihydroceramide and Akt.
autophagy
hydroxytriolein
lipid composition and cancer treatment
membrane lipid therapy
triple negative breast cancer
Journal
Oncotarget
ISSN: 1949-2553
Titre abrégé: Oncotarget
Pays: United States
ID NLM: 101532965
Informations de publication
Date de publication:
02 Apr 2019
02 Apr 2019
Historique:
received:
29
01
2019
accepted:
04
03
2019
entrez:
10
5
2019
pubmed:
10
5
2019
medline:
10
5
2019
Statut:
epublish
Résumé
The plasma membrane is an attractive target for new anticancer drugs, not least because regulating its lipid structure can control multiple signaling pathways involved in cancer cell proliferation, differentiation and survival. Accordingly, the novel anticancer drug hydroxytriolein (HTO) was designed to interact with and regulate the composition and structure of the membrane, which in turn controls the interaction of amphitropic signaling membrane proteins with the lipid bilayer. Changes in signaling provoked by HTO impair the growth of triple negative breast cancer (TNBC) cells, aggressive breast tumor cells that have a worse prognosis than other types of breast cancers and for which there is as yet no effective targeted therapy. HTO alters the lipid composition and structure of cancer cell membranes, inhibiting the growth of MDA-MB-231 and BT-549 TNBC cells
Identifiants
pubmed: 31069012
doi: 10.18632/oncotarget.26824
pii: 26824
pmc: PMC6493458
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2486-2507Déclaration de conflit d'intérêts
CONFLICTS OF INTEREST DJL, MI, MT, XB and PVE declare that are shareholders in several biotech companies: Lipopharma Therapeutics (DJL, MI, MT, XB and PVE), Neural Therapies (XB and PVE), Pharmaconcept (XB and PVE), Neurofix (PVE) and Ability Therapeutics (PVE).
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