Interactions in the (Pre)metastatic Niche Support Metastasis Formation.
extracellular matrix
immune cells
metastatic niche
nutrient environment
premetastatic niche
stromal cells
tumor environment
tumor secreted factors
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2019
2019
Historique:
received:
09
12
2018
accepted:
12
03
2019
entrez:
10
5
2019
pubmed:
10
5
2019
medline:
10
5
2019
Statut:
epublish
Résumé
Metastasis formation is the leading cause of death in cancer patients. Thus, understanding and targeting this process is an unmet need. Crucial steps during the establishment of metastases include the (pre)metastatic niche formation. This process relies on the interaction of the primary tumor with the environment of distant organs (premetastatic niche) and the interaction of cancer cells with their environment when arriving in a distant organ (metastatic niche). Here, we summarize the current knowledge on the interactions in the tumor environment that result in (pre)metastatic niche formation, specifically in the context of tumor secreted factors, extracellular matrix, immune as well as stromal cells, and nutrient availability. We further highlight strategies to disrupt these interactions as therapeutic interventions against metastases.
Identifiants
pubmed: 31069166
doi: 10.3389/fonc.2019.00219
pmc: PMC6491570
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
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