Synthesis and in vitro activity of new biguanide-containing dendrimers on pathogenic isolates of Acanthamoeba polyphaga and Acanthamoeba griffini.
Acanthamoeba
/ classification
Acanthamoeba Keratitis
/ drug therapy
Amebicides
/ pharmacology
Animals
Biguanides
/ pharmacology
Cell Line, Tumor
Chlorhexidine
/ analogs & derivatives
Contact Lens Solutions
Dendrimers
/ pharmacology
Encephalitis
/ drug therapy
HeLa Cells
Humans
Trophozoites
/ drug effects
Acanthamoeba
Biguanide
Dendrimers
Genotype T3
Genotype T4
Trophozoites
Journal
Parasitology research
ISSN: 1432-1955
Titre abrégé: Parasitol Res
Pays: Germany
ID NLM: 8703571
Informations de publication
Date de publication:
Jun 2019
Jun 2019
Historique:
received:
03
12
2018
accepted:
29
04
2019
pubmed:
10
5
2019
medline:
18
7
2019
entrez:
10
5
2019
Statut:
ppublish
Résumé
The genus Acanthamoeba can cause Acanthamoeba keratitis (AK) and granulomatous amoebic encephalitis (GAE). The treatment of these illnesses is hampered by the existence of a resistance stage that many times causes infection relapses. In an attempt to add new agents to our chemotherapeutic arsenal against acanthamebiasis, two Acanthamoeba isolates were treated in vitro with newly synthesized biguanide dendrimers. Trophozoite viability analysis and ultrastructural studies showed that dendrimers prevent encystment by lysing the cellular membrane of the amoeba. Moreover, one of the dendrimers showed low toxicity when tested on mammalian cell cultures, which suggest that it might be eventually used as an amoebicidal drug or as a disinfection compound in contact lens solutions.
Identifiants
pubmed: 31069536
doi: 10.1007/s00436-019-06341-7
pii: 10.1007/s00436-019-06341-7
doi:
Substances chimiques
Amebicides
0
Biguanides
0
Contact Lens Solutions
0
Dendrimers
0
chlorhexidine gluconate
MOR84MUD8E
Chlorhexidine
R4KO0DY52L
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1953-1961Références
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