Application of Dual-Cyclodextrin Systems in Capillary Electrophoresis Enantioseparations.

Cyclodextrins / chemistry Electrolytes / chemistry Electrophoresis, Capillary / methods Pharmaceutical Preparations / chemistry Stereoisomerism
Acidic compounds Capillary electrophoresis Dual-cyclodextrin system Neutral compounds

Journal

Methods in molecular biology (Clifton, N.J.)
ISSN: 1940-6029
Titre abrégé: Methods Mol Biol
Pays: United States
ID NLM: 9214969

Informations de publication

Date de publication:
2019
Historique:
entrez: 10 5 2019
pubmed: 10 5 2019
medline: 23 1 2020
Statut: ppublish

Résumé

The enantioseparation of acidic and neutral compounds can be successfully achieved in capillary electrophoresis (CE) using dual-cyclodextrin (CD) systems. This chapter describes how to separate the enantiomers of acidic or neutral substances using dual-CD systems made up of a negatively charged CD derivative, i.e., sulfobutyl-β-CD or carboxymethyl-β-CD, in combination with a neutral one, namely heptakis(2,3,6-tri-O-methyl)-β-CD. An acidic compound (carprofen) and a weakly acidic drug (pentobarbital) were selected as model compounds.

Identifiants

DOI: 10.1007/978-1-4939-9438-0_19 PMID: 31069744
pubmed: 31069744
doi: 10.1007/978-1-4939-9438-0_19
doi:

Substances chimiques

Cyclodextrins 0
Electrolytes 0
Pharmaceutical Preparations 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

357-364

Auteurs

Anne-Catherine Servais (AC)

Laboratory for the Analysis of Medicines, Department of Pharmaceutical Sciences, CIRM, Quartier Hôpital, University of Liège, Liège, Belgium.

Marianne Fillet (M)

Laboratory for the Analysis of Medicines, Department of Pharmaceutical Sciences, CIRM, Quartier Hôpital, University of Liège, Liège, Belgium. marianne.fillet@uliege.be.

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Classifications MeSH

questionsmedicales.fr › Glucides › Polyosides › Glucanes › Amidon › Dextrine › Cyclodextrines › Application of Dual-Cyclodextrin Systems in...
questionsmedicales.fr › Produits chimiques inorganiques › Électrolytes › Application of Dual-Cyclodextrin Systems in...
questionsmedicales.fr › Techniques d'investigation › Techniques électrochimiques › Électrophorèse › Électrophorèse capillaire › Application of Dual-Cyclodextrin Systems in...
questionsmedicales.fr › Préparations pharmaceutiques › Application of Dual-Cyclodextrin Systems in...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes de chimie organique › Isomérie › Stéréoisomérie › Application of Dual-Cyclodextrin Systems in...