Enantioseparations in Nonaqueous Capillary Electrophoresis Using Charged Cyclodextrins.

Cyclodextrins / chemistry Electrophoresis, Capillary / methods Pharmaceutical Preparations / chemistry Stereoisomerism
Acidic compounds Basic compounds Nonaqueous capillary electrophoresis Single-isomer charged β-cyclodextrin derivatives

Journal

Methods in molecular biology (Clifton, N.J.)
ISSN: 1940-6029
Titre abrégé: Methods Mol Biol
Pays: United States
ID NLM: 9214969

Informations de publication

Date de publication:
2019
Historique:
entrez: 10 5 2019
pubmed: 10 5 2019
medline: 23 1 2020
Statut: ppublish

Résumé

The enantioseparation of acidic and basic compounds can be successfully achieved in nonaqueous capillary electrophoresis (NACE) using single-isomer charged β-cyclodextrin (β-CD) derivatives of opposite charge to that of the analytes. This chapter describes how to separate the enantiomers of three basic substances selected as model compounds, i.e., alprenolol, bupranolol, and terbutaline, using the negatively charged heptakis(2,3-di-O-acetyl-6-O-sulfo)-β-CD (HDAS-β-CD). The enantiomers of three acidic drugs (tiaprofenic acid, suprofen, and flurbiprofen) are resolved using a monosubstituted amino β-CD derivative, namely 6-monodeoxy-6-mono(3-hydroxy)propylamino-β-CD (PA-β-CD).

Identifiants

DOI: 10.1007/978-1-4939-9438-0_21 PMID: 31069746
pubmed: 31069746
doi: 10.1007/978-1-4939-9438-0_21
doi:

Substances chimiques

Cyclodextrins 0
Pharmaceutical Preparations 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

373-381

Auteurs

Anne-Catherine Servais (AC)

Laboratory for the Analysis of Medicines, Department of Pharmaceutical Sciences, CIRM, Quartier Hôpital, University of Liège, Liège, Belgium. acservais@uliege.be.

Marianne Fillet (M)

Laboratory for the Analysis of Medicines, Department of Pharmaceutical Sciences, CIRM, Quartier Hôpital, University of Liège, Liège, Belgium.

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Classifications MeSH

questionsmedicales.fr › Glucides › Polyosides › Glucanes › Amidon › Dextrine › Cyclodextrines › Enantioseparations in Nonaqueous Capillary...
questionsmedicales.fr › Techniques d'investigation › Techniques électrochimiques › Électrophorèse › Électrophorèse capillaire › Enantioseparations in Nonaqueous Capillary...
questionsmedicales.fr › Préparations pharmaceutiques › Enantioseparations in Nonaqueous Capillary...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes de chimie organique › Isomérie › Stéréoisomérie › Enantioseparations in Nonaqueous Capillary...